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Are couple-based interventions more effective than interventions delivered to individuals in promoting HIV protective behaviors? A meta-analysis

机译：在促进艾滋病毒保护行为方面，基于夫妇的干预措施是否比针对个人的干预措施更有效？荟萃分析

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Despite several advantages to bringing couples together to learn how to protect themselves and new-born children from the risk of HIV infection, most interventions are designed for individuals or groups, not for dyads. This meta-analysis provides a direct test of whether couple-based interventions are more effective in promoting HIV protective behaviors than interventions delivered to individuals. We conducted systematic searches of five electronic databases and 60 journals. Eligible studies were controlled trials or prospective cohort designs; evaluated a couple-based intervention compared to an individual-level intervention; assessed at least one HIV prevention outcome (e.g., protective sex, drug use, HIV testing, medication adherence, and sexually transmitted infections [STI]); and were published between 1988 and 2014. Fifteen interventions, including 21,882 participants from China, Kenya, Rwanda, Tanzania, Trinidad, Zambia, and the USA, were evaluated. The results of random-effects models showed statistically significant intervention effects for protective sex (OR = 1.60, 95% CI = 1.21, 2.11), HIV testing (OR = 1.79, 95% CI = 1.31, 2.45), and Nevirapine uptake (OR = 1.51, 95% CI = 1.02, 2.24). The evidence demonstrates the usefulness of couple-based interventions in protecting individuals, partners, and new-born children from the risk of HIV transmission and infection.
机译：尽管将夫妻聚集在一起以学习如何保护自己和新生婴儿免受HIV感染的风险有许多优势，但大多数干预措施都是针对个人或团体的，而不是针对双胞胎的。这项荟萃分析直接检验了基于夫妻的干预是否比提供给个人的干预更有效地促进了HIV的保护行为。我们对5个电子数据库和60种期刊进行了系统搜索。符合条件的研究为对照试验或前瞻性队列设计;与个人干预相比，评估了基于夫妻的干预;评估至少一项HIV预防结果（例如，保护性行为，吸毒，HIV测试，药物依从性和性传播感染[STI]）;并于1988年至2014年之间发表。对15种干预措施进行了评估，包括来自中国，肯尼亚，卢旺达，坦桑尼亚，特立尼达，赞比亚和美国的21882名参与者。随机效应模型的结果显示，在保护性行为（OR = 1.60，95％CI = 1.21，2.11），HIV测试（OR = 1.79，95％CI = 1.31、2.45）和奈韦拉平摄取（OR = 1.51，95％CI = 1.02，2.24）。证据表明，以夫妇为基础的干预措施对于保护个人，伴侣和新生婴儿免受HIV传播和感染的危险是有用的。

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