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首页> 外文期刊>AIDS care. >Harmful alcohol consumption and patterns of substance use in HIV-infected patients receiving antiretrovirals (ANRS-EN12-VESPA Study): relevance for clinical management and intervention.
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Harmful alcohol consumption and patterns of substance use in HIV-infected patients receiving antiretrovirals (ANRS-EN12-VESPA Study): relevance for clinical management and intervention.

机译：在接受抗逆转录病毒药物的HIV感染患者中有害饮酒和物质使用方式（ANRS-EN12-VESPA研究）：与临床管理和干预有关。

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Alcohol abuse affects secondary prevention and disease progression in HIV-infected patients, and adherence and response to treatment in those chronically treated. The objective of this study was to estimate the prevalence of harmful alcohol consumption (HAC) using various indicators and identify which groups of patients may require specific targeted interventions for HAC risk reduction. A cross-sectional survey, based on a random sample representative of people living with HIV/AIDS (PLWHA) was carried out in 102 French hospital departments delivering HIV care. As alcohol abuse is particularly detrimental to patients receiving highly active antiretroviral therapy (HAART), we focused only on those individuals receiving HAART with complete alcohol assessment (CAGE, AUDIT-C, regular binge drinking, N=2340). Collected information included medical and socio-demographic data, HIV risk behaviors, adherence to treatment and substance and alcohol use, together with depression, anxiety, and experience of attempted suicide or sex work. HAC prevalence was evaluated as follows: 12% (CAGE score > or =2), 27% (AUDIT-C), and 9% (regular binge drinking). Three groups were at higher risk of HAC: men who have sex with men using stimulants, polydrug users, and to a lesser degree, ex-drug users. Innovative intervention strategies to reduce HAC and improve HIV prevention and HAART adherence in various PLWHA populations need urgent testing and implementation. Such interventions for alcohol risk reduction remain central to promoting improved HIV prevention and assuring HAART effectiveness in these populations.
机译：酗酒会影响HIV感染患者的二级预防和疾病进展，以及长期治疗患者的依从性和对治疗的反应。这项研究的目的是使用各种指标来评估有害酒精消费（HAC）的患病率，并确定哪些患者群体可能需要针对性的干预措施以降低HAC风险。在法国的102个提供艾滋病毒护理服务的医院部门中，基于随机样本的艾滋病毒/艾滋病感染者（PLWHA）进行了横断面调查。由于滥用酒精对接受高活性抗逆转录病毒疗法（HAART）的患者尤其有害，因此我们仅关注接受全面酒精评估（CAGE，AUDIT-C，定期狂饮，N = 2340）的接受HAART的患者。收集的信息包括医学和社会人口统计学数据，艾滋病毒的危险行为，对治疗的依从性以及药物和酒精的使用，以及抑郁症，焦虑症和未遂自杀或性工作的经历。 HAC患病率的评估如下：12％（CAGE评分>或= 2），27％（AUDIT-C）和9％（定期狂饮）。三类人群发生HAC的风险较高：与使用兴奋剂的男性发生性行为的男性，使用多种药物的人和较少使用过药物的男性。减少艾滋病病毒感染率和改善艾滋病毒预防和艾滋病在各种艾滋病病毒感染者中的依从性的创新干预策略需要紧急测试和实施。减少酒精风险的此类干预措施仍然是在这些人群中促进改善HIV预防和确保HAART有效性的关键。

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