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首页> 外文期刊>AIDS care. >First presentation for care of HIV-infected patients with low CD4 cell count in Lyon, France: Risk factors and consequences for survival
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First presentation for care of HIV-infected patients with low CD4 cell count in Lyon, France: Risk factors and consequences for survival

机译：法国里昂首次发表有关艾滋病毒感染的低CD4细胞计数患者的介绍：危险因素和生存后果

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To identify the risk factors associated with presentation for care with CD4 cell count 200 cells/mm 3 and death in HIV-infected patients in Lyon, France. Data were analyzed on participants from mid-1992 to December 2006 in the Lyon section of the French Hospital Database on HIV Infection. Patients were stratified into two categories according to CD4 cell count at first presentation for care in University of Lyon hospitals: Group 1 (Gr1) patients with CD4 200 cells/mm 3 and Group 2 (Gr2) patients with CD4 200 cells/mm 3. Multivariate logistic regression assessed the risk factors associated with first presentation for care with CD4 200 cells/mm 3. Survival was analyzed according to the Cox regression model. Among 3569 eligible patients (838 females and 2731 males, mean age: 36.310.3 years), 1139 (31.9%) were categorized as Gr1. The factors associated with first presentation for care with CD4 200 cells/mm 3 were: older age, male gender, route of HIV transmission, migrant populations, geographical areas other than Rhne-Alpes, and access to care in 1992-1997. Overall mortality was higher in Gr1 than in Gr2 (24.4% [278/1139] vs. 4.1% [101/2430]; p0.001). The risk of death was 5.81 [4.61-7.32] in Gr1 compared to Gr2. In addition to CD4 cell count, age and enrollment periods for care were factors independently related to death. Despite public health efforts in Lyon, one-third of HIV-infected patients reach the health care system with CD4 cell count 200 cells/mm 3, which was linked with higher mortality.
机译：在法国里昂，确定与CD4细胞计数为200细胞/ mm 3的护理表现以及死亡的HIV感染患者相关的危险因素。在1992年中至2006年12月期间，在法国医院艾滋病毒感染数据库的里昂部分对参与者的数据进行了分析。首次在里昂大学医院就诊时，根据CD4细胞计数将患者分为两类：CD4 200细胞/ mm 3的第1组（Gr1）患者和CD4> 200细胞/ mm 3的第2组（Gr2）患者。多元logistic回归评估与首次就诊CD4 200细胞/ mm 3相关的危险因素3.根据Cox回归模型分析生存率。在3569名合格患者（838名女性和2731名男性，平均年龄：36.310.3岁）中，有1139名（31.9％）被归类为Gr1。与首次就CD4 200细胞/ mm 3进行护理有关的因素是：年龄，男性，HIV传播途径，移民人口，除Rhne-Alpes以外的地理区域以及1992-1997年获得护理的机会。 Gr1的总死亡率高于Gr2（24.4％[278/1139]对4.1％[101/2430]; p <0.001）。与Gr2相比，Gr1的死亡风险为5.81 [4.61-7.32]。除了CD4细胞计数外，年龄和就诊时间也是与死亡独立相关的因素。尽管在里昂开展了公共卫生工作，但仍有三分之一的HIV感染患者以200细胞/ mm 3的CD4细胞计数进入卫生保健系统，这与更高的死亡率有关。

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