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首页> 外文期刊>AIDS care. >Acceptability of an 'on-demand' pre-exposure HIV prophylaxis trial among men who have sex with men living in France.
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Acceptability of an 'on-demand' pre-exposure HIV prophylaxis trial among men who have sex with men living in France.

机译：与法国男性发生性关系的男性按需进行的“暴露前”艾滋病毒预防试验的可接受性。

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Although predictors of willingness to take daily, self-administered pre-exposure HIV prophylaxis (PrEP) for men who have sex with men (MSM) have been studied in the context of several PrEP trials internationally, little is known about MSM interested in participating in a trial on the use of PrEP on an "on -demand" basis, i.e., taking a first dose of combined tenofovir/emtricitabine a few hours before possible HIV sexual exposure and a second dose a few hours afterwards. A double-blind placebo randomized PrEP trial will soon begin in France to evaluate the effectiveness of PrEP in terms of reducing HIV infection rates, among MSM self-administering "on-demand" PrEP. To assess potential participants' characteristics associated with willingness to participate in the trial and identify barriers and facilitators to implementation, MSM completed a self-administered questionnaire, distributed via gay venues and community websites. Among the 443 respondents who reported being HIV-negative, 40% reported being interested in participating. Factors independently associated with interest included: reporting lower educational level, more than 20 male sexual partners in the previous year, reporting unprotected anal sex with casual partners and preferring PrEP follow-up visits in a devoted area within a hospital. There is great interest in participating in a future "on-demand" PrEP trial among HIV-negative MSM and particularly in those at potentially high risk of HIV exposure. Providing confidentiality and tailored counseling during PrEP follow-up are important issues.
机译：尽管在国际上多项PrEP试验的背景下，已经研究出了与男性发生性关系（MSM）的男性愿意每天服用自我管理的暴露前HIV预防（PrEP）意愿的预测因素，但对MSM感兴趣参与的知之甚少一项“按需”使用PrEP的试验，即在可能的HIV性暴露前几小时服用第一剂替诺福韦/恩曲他滨联合，第二小时几小时。在MSM自用“按需” PrEP中，一项双盲安慰剂随机PrEP试验将很快在法国开始，以评估PrEP在降低HIV感染率方面的有效性。为了评估与参加试验的意愿相关的潜在参与者的特征并确定实施的障碍和促进者，MSM完成了一份自行管理的问卷，该问卷通过同性恋场所和社区网站分发。在报告为HIV阴性的443位受访者中，有40％报告对参与感兴趣。与兴趣独立相关的因素包括：报告的文化程度较低，上一年有20多个男性性伴侣，报告与休闲伴侣的未保护性肛交，并且更喜欢在医院内的专用区域进行PrEP随访。对参与HIV阴性MSM的未来“按需” PrEP试验的兴趣很大，尤其是那些可能暴露于HIV高风险中的人。在PrEP随访期间提供保密和量身定制的咨询是重要的问题。

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