...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>AIDS care. >Civil society perspectives on negative biomedical HIV prevention trial results and implications for future trials
【24h】

Civil society perspectives on negative biomedical HIV prevention trial results and implications for future trials

机译：民间社会对艾滋病毒生物医学预防阴性试验结果的看法及其对未来试验的影响

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Community engagement is crucial to ongoing development and testing of sorely needed new biomedical HIV prevention technologies. Yet, negative trial results raise significant challenges for community engagement in HIV prevention trials, including the early termination of the Cellulose Sulfate microbicide trial and two Phase IIb HIV vaccine trials (STEP and Phambili). The present study aimed to explore the perspectives and experiences of civil society organization (CSO) representatives regarding negative HIV prevention trial results and perceived implications for future trials. We conducted in-depth interviews with 14 respondents from a broad range of South African and international CSOs, and analyzed data using thematic analysis. CSO representatives reported disappointment in response to negative trial results, but acknowledged such outcomes as inherent to clinical research. Respondents indicated that in theory negative trial results seem likely to impact on willingness to participate in future trials, but that in practice people in South Africa have continued to volunteer. Negative trial results were described as having contributed to improving ethical standards, and to a re-evaluation of the scientific agenda. Such negative results were identified as potentially impacting on funding for trials and engagement activities. Our findings indicate that trial closures may be used constructively to support opportunities for reflection and renewed vigilance in strategies for stakeholder engagement, communicating trial outcomes, and building research literacy among communities; however, these strategies require sustained resources for community engagement and capacity-building.
机译：社区参与对于持续开发和测试急需的新的生物医学艾滋病毒预防技术至关重要。然而，阴性试验结果给社区参与艾滋病毒预防试验提出了重大挑战，包括提前终止硫酸纤维素杀微生物剂试验和两项IIb期HIV疫苗试验（STEP和Phambili）。本研究旨在探讨民间社会组织（CSO）代表对艾滋病毒预防试验的负面结果以及对未来试验的潜在影响的观点和经验。我们对来自南非和国际民间社会组织的14位受访者进行了深入采访，并使用主题分析对数据进行了分析。 CSO代表对试验结果阴性表示失望，但承认此类结果是临床研究固有的。受访者表示，从理论上讲，阴性试验结果似乎可能会影响参加未来试验的意愿，但实际上，南非人民仍在自愿。负面的审判结果被描述为有助于提高道德标准，并重新评估了科学议程。这些负面结果被认为可能影响试验和参与活动的资金。我们的研究结果表明，试验结案可用于建设性地支持利益相关者参与，沟通试验结果和在社区之间建立研究素养的战略中进行反思和重新保持警惕的机会;但是，这些战略需要持续的资源用于社区参与和能力建设。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号