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Combined effects of HIV and marijuana use on neurocognitive functioning and immune status

机译:HIV和大麻使用对神经认知功能和免疫状态的综合影响

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The current study examined the independent and combined effects of HIV and marijuana (MJ) use (no use, light use, and moderate-to-heavy use) on neurocognitive functioning among a convenience sample of HIV-positive (HIV+) and HIV-negative (HIV-) individuals recruited from HIV community care clinics and advertisements in the Greater Los Angeles area. MJ users consisted of individuals who reported regular use of MJ for at least 12 months, with last reported use within the past month. Participants included 89 HIV+ (n = 55) and HIV- (n = 34) individuals who were grouped into non-users, light users, and moderate-to-heavy users based on self-reported MJ use. Participants were administered a brief cognitive test battery and underwent laboratory testing for CD4 count and viral load. HIV+ individuals demonstrated lower performance on neurocognitive testing than controls, and moderate-to-heavy MJ users performed more poorly on neurocognitive testing than light users or non-users. Moderate-to-heavy HIV+ users performed significantly lower on learning/memory than HIV- moderate-to-heavy users (M-D = -8.34; 95% CI: -16.11 to -0.56) as well as all other comparison groups. In the domain of verbal fluency, HIV+ light users outperformed HIV- light users (M-D = 7.28; 95% CI: 1.62-12.39), but no HIV group differences were observed at other MJ use levels. HIV+ MJ users demonstrated lower viral load (M-D = -0.58; 95% CI: -1.30 to 0.14) and higher CD4 count than non-users (M-D = 137.67; 95% CI: 9.48-265.85). The current study findings extend the literature by demonstrating the complex relationship between HIV status and MJ use on neurocognitive and clinical outcomes.
机译:当前的研究在便利的HIV阳性(HIV +)和HIV阴性样本中,研究了HIV和大麻(MJ)使用(不使用,轻度使用和中度至重度使用)对神经认知功能的独立和综合影响。 (HIV-)个人从大洛杉矶地区的HIV社区护理诊所和广告中招募。 MJ用户包括报告了至少12个月定期使用MJ,最近一次报告使用在过去一个月内的个人。参与者包括89位HIV +(n = 55)和HIV-(n = 34)个体,这些个体根据自我报告的MJ使用情况分为非使用者,轻度使用者和中度至重度使用者。参与者接受了简短的认知测试,并进行了CD4计数和病毒载量的实验室测试。 HIV +个体在神经认知测试中表现出比对照组低的表现,中重度MJ用户在神经认知测试中的表现比轻度或非轻度用户更差。中度至重度HIV +使用者和学习中/记忆方面的表现显着低于HIV中度至重度使用者(M-D = -8.34; 95%CI:-16.11至-0.56)以及所有其他比较组。在言语流畅度方面,HIV +轻度用户优于HIV轻度用户(M-D = 7.28; 95%CI:1.62-12.39),但在其他MJ使用水平下未观察到HIV组差异。与非使用者相比,HIV + MJ使用者表现出较低的病毒载量(M-D = -0.58; 95%CI:-1.30至0.14)和较高的CD4计数(M-D = 137.67; 95%CI:9.48-265.85)。当前的研究结果通过证明HIV状况和MJ在神经认知和临床结局方面的复杂关系扩展了文献。

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