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首页> 外文期刊>The journals of gerontology.Series A. Biological sciences and medical sciences >Three Doses of Vitamin D and Cognitive Outcomes in Older Women: A Double-Blind Randomized Controlled Trial
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Three Doses of Vitamin D and Cognitive Outcomes in Older Women: A Double-Blind Randomized Controlled Trial

机译：老年女性的三剂维生素D和认知结果：双盲随机对照试验

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摘要

Vitamin D may affect cognitive performance, but previous studies are either short term or observational. We conducted a randomized controlled trial of vitamin D supplementation on domain-specific cognitive measures in postmenopausal women. Overweight/obese women with serum 25-hydroxyvitamin D (25OHD) levels less than 30 ng/mL were recruited. Vitamin D-3 supplementation (600, 2,000, or 4,000 IU/d) was randomly assigned in a double-blinded manner for 1 year. Serum 25-hydroxyvitamin D, osteocalcin (total and undercarboxylated), amyloid beta, parathyroid hormone, and estradiol were analyzed before and after supplementation. Cognitive tests were administered after treatment. The women (58 +/- 6 years; body mass index, 30.0 +/- 3.5 kg/m(2)) had a baseline serum 25-hydroxyvitamin D level of 22.6 +/- 5.8 ng/mL that increased to 30.2 +/- 5.6, 36.0 +/- 4.9, and 40.8 +/- 7.0 ng/mL in the 600, 2,000, and 4,000 IU/d groups, respectively (p < .001). Participants taking 2,000 IU/d compared to other doses performed better in learning and memory tests (p < .05), yet the 4,000 IU/d group had a slower reaction time compared to the 600 IU/d group. Multiple regression indicated that serum undercarboxylated osteocalcin predicted tasks associated with reaction time and executive function, whereas body mass index and parathyroid hormone negatively predicted reaction time and executive function (p <= .01). These data suggest that vitamin D has differential effects on domain-specific cognitive measures and that a higher dose may negatively affect reaction time.
机译：维生素D可能影响认知性能，但之前的研究是短期或观察性的。我们进行了维生素D随机对照试验，对绝经后妇女的域特异性认知措施进行了补充。募集患有血清25-羟基乙多素D（25Ohd）水平小于30ng / ml的血清/肥胖的妇女。维生素D-3补充（600,2,000或4,000 IU / D）以双盲方式随机分配1年。在补充之前和之后，分析了血清25-羟基乙多蛋白D，骨钙蛋白（总和羧化），淀粉样蛋白β，甲状旁腺激素和雌二醇。治疗后施用认知试验。女性（58 +/- 6岁;体重指数，30.0 +/- 3.5 kg / m（2））具有32.6 +/- 5.8 ng / ml的基线血清25-羟基vitamin d水平增加至30.2 + / - 600,2,000和4,000 IU / D组中的5.6,36.0 +/- 4.9和40.8 +/- 7.0 ng / ml（P <.001）。与其他剂量相比，参与者与学习和记忆测试中的其他剂量相比（P <.05），但与600 IU / D组相比，4,000 IU / D组的反应时间较慢。多元回归表明，与反应时间和执行功能相关的血清乳糖预测任务，而体重指数和甲状旁腺激素带负面预测的反应时间和执行功能（P <= .01）。这些数据表明维生素D对域特异性认知措施具有差异影响，并且更高的剂量可能对反应时间产生负面影响。

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