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首页> 外文期刊>The journals of gerontology.Series A. Biological sciences and medical sciences >Cytomegalovirus Seropositivity Predicts a Decline in the T Cell But Not the Antibody Response to Influenza in Vaccinated Older Adults Independent of Type 2 Diabetes Status
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Cytomegalovirus Seropositivity Predicts a Decline in the T Cell But Not the Antibody Response to Influenza in Vaccinated Older Adults Independent of Type 2 Diabetes Status

机译：Cytomegalovirus血液阳性预测T细胞的下降，但不是疫苗的老年人在疫苗的老年人中对流感的抗体反应，独立于2型糖尿病状态

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Type 2 diabetes mellitus (T2DM) and persistent cytomegalovirus (CMV) infection are postulated contributors to inflammatory processes that impact on the age-related decline in T-cell responses to influenza vaccination. Older subjects with T2DM (n = 30) and healthy aged controls (n = 40) were enrolled and received influenza vaccination in this study. Serum inflammatory markers and CMV serostatus were measured. Pre-to post-vaccination changes in serum antibody titers to the A/H3N2 strain, and levels of granzyme B (GrB, cytotoxic T lymphocytes) in lysates and cytokines in supernatants from influenza A/H3N2-challenged peripheral blood mononuclear cells were measured. We found no difference between the T2DM and healthy groups in the immune responses measured. However, CMV serostatus was a key determinant of the GrB response to influenza challenge; CMV+ subjects had low levels of inducible GrB (iGrB) activity in response to influenza challenge. In contrast, the serum antibody response to the A/H3N2 vaccine strain did not differ with CMV serostatus, and serum levels of the inflammatory marker, similar to 2-microglobulin, were positively correlated with age, T2DM, and serum IL-10 levels. In conclusion, CMV seropositivity associated with a decline in GrB responses to influenza may predict increased susceptibility to influenza in older adults.
机译：2型糖尿病（T2DM）和持续的巨细胞病毒（CMV）感染是假定对炎症过程的贡献者，这些贡献者会影响与流感疫苗接种的T细胞应答的年龄相关的下降。在本研究中注册并接受了具有T2DM（n = 30）和健康老年对照（n = 40）的较旧的受试者。测量血清炎症标记和CMV血清霉菌。测定了测量来自流感A / H3N2攻击外周血单核细胞的裂解物和裂解物中裂解物和细胞因子的血清抗体滴度的血清抗体滴度的变化，以及裂解物中的裂解物和细胞因子的水平。我们发现在测量的免疫反应中的T2DM和健康群之间没有区别。然而，CMV Serostatus是对流感挑战的GRB反应的关键决定因素; CMV +受试者响应流感挑战的诱导型GRB（IGB）活性较低。相反，对A / H3N2疫苗菌株的血清抗体响应与CMV Serostatum没有不同的不同，并且类似于2微球蛋白的炎症标记的血清水平与年龄，T2DM和血清IL-10水平正相关。总之，与对流感的GRB响应下降相关的CMV血清阳性可能预测老年人对流感的易感性增加。

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