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首页> 外文期刊>The journals of gerontology.Series A. Biological sciences and medical sciences >Physiological Dysregulation as a Promising Measure of Robustness and Resilience in Studies of Aging and a New Indicator of Preclinical Disease
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Physiological Dysregulation as a Promising Measure of Robustness and Resilience in Studies of Aging and a New Indicator of Preclinical Disease

机译：生理失调作为衰老研究和临床前疾病新指标的稳健性和恢复能力的有希望的稳健性和恢复力

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Recently suggested novel implementation of the statistical distance measure (D-M) for evaluating physiological dysregulation (PD) in aging individuals (based on measuring deviations of multiple biomarkers from baseline or normal physiological states) allows reducing high-dimensional biomarker space into a single PD estimate. Here we constructed D-M using biomarker profiles from FRAMCOHORT (Framingham Heart Study) and CHS (Cardiovascular Health Study) Research Materials obtained from the NHLBI Biologic Specimen and Data Repository Information Coordinating Center, and estimated effect of PD on total survival, onset of unhealthy life (proxy for robustness) and survival following the onset of unhealthy life (proxy for resilience). We investigated relationships between PD and declines in stress resistance and adaptive capacity not directly observed in data. PD was more strongly associated with the onset of unhealthy life than with survival after disease suggesting that declines in robustness and resilience with age may have overlapping as well as distinct mechanisms. We conclude that multiple deviations of physiological markers from their normal states (reflected in higher PD) may contribute to increased vulnerability to many diseases and precede their clinical manifestation. This supports potential use of PD in health care as a preclinical indicator of transition from healthy to unhealthy state.
机译：最近建议在老化个体中评估生理失调（Pd）的统计距离测量（D-M）的新颖的实施（基于来自基线或正常生理状态的多种生物标志物的测量偏差），允许将高维生物标志物空间减少到单个PD估计中。在这里，我们构建了使用来自Framcohort（Framingham心脏研究）和CHS（心血管健康研究）的生物标志物简介的DM，从NHLBI生物学标本和数据储存库信息协调中心获得的研究资料，以及PD对总存活的估计效果，发作不健康的生活（鲁棒性的代理）和不健康生活发作后的生存（适用于弹性的代理）。我们调查了PD之间的关系，并在数据中未直接观察到的应力阻力和自适应容量。 PD与不健康的生命的发作更强烈地关联，而不是在疾病后生存，这表明稳健性和增长的稳健性下降可能具有重叠以及明显的机制。我们得出结论，生理标志物与正常状态的多重偏差（在较高PD中反映）可能有助于增加对许多疾病的脆弱性，并在其临床表现之前。这支持潜在使用PD在医疗保健中作为从健康到不健康的状态过渡的临床前指标。

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