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首页> 外文期刊>The journals of gerontology.Series A. Biological sciences and medical sciences >Electrical Properties Assessed by Bioelectrical Impedance Spectroscopy as Biomarkers of Age-related Loss of Skeletal Muscle Quantity and Quality
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Electrical Properties Assessed by Bioelectrical Impedance Spectroscopy as Biomarkers of Age-related Loss of Skeletal Muscle Quantity and Quality

机译：通过生物电阻抗光谱评估的电气性能作为与年龄相关的骨骼肌数量和质量的生物标志物

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摘要

Skeletal muscle, in addition to being comprised of a heterogeneous muscle fiber population, also includes extracellular components that do not contribute to positive tensional force production. Here we test segmental bioelectrical impedance spectroscopy (S-BIS) to assess muscle intracellular mass and composition. S-BIS can evaluate electrical properties that may be related to muscle force production. Muscle fiber membranes separate the intracellular components from the extracellular environment and consist of lipid bilayers which act as an electrical capacitor. We found that S-BIS measures accounted for similar to 85% of the age-related decrease in appendicular muscle power compared with only similar to 49% for dual-energy x-ray absorptiometry (DXA) measures. Indices of extracellular (noncontractile) and cellular (contractile) compartments in skeletal muscle tissues were determined using the Cole-Cole plot from S-BIS measures. Characteristic frequency, membrane capacitance, and phase angle determined by Cole-Cole analysis together presented a S-BIS complex model that explained similar to 79% of interindividual variance of leg muscle power. This finding underscores the value of S-BIS to measure muscle composition rather than lean mass as measured by DXA and suggests that S-BIS should be highly informative in skeletal muscle physiology.
机译：除了由异质肌纤维群组成外，骨骼肌还包括对阳性张力生产没有贡献的细胞外组分。在这里，我们测试节段性的生物电阻抗谱（S-BIS）以评估肌肉细胞内质量和组合物。 S-BIS可以评估可能与肌肉生产相关的电性能。肌纤维膜与细胞外环境分离细胞内部件，由脂质双层组成，其充当电容器。我们发现S-BIS措施占与双能X射线吸收测量（DXA）措施的49％相比，占与年龄相关的龄相关的85％与49％相比。使用来自S-BIS措施的COLE-COLE图测定骨骼肌组织中细胞外（不可触发）和细胞（收缩）隔室的索引。由COLE-COLE分析确定的特征频率，膜电容和相角呈现了S-BIS复杂模型，其解释了腿部肌肉力量的相互作用方差的79％。该发现强调了S-BIS测量肌肉组成而不是通过DXA测量的瘦物质，并表明S-BIS应该在骨骼肌生理学中具有高度信息。

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