Mechanisms of age-related cognitive change and targets for intervention: epigenetics.

Kenneth S Kosik; Peter R Rapp; Naftali Raz; Scott A Small; J David Sweatt; Li-Huei Tsai

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Mechanisms of age-related cognitive change and targets for intervention: epigenetics.

机译：与年龄相关的认知变化和疗程目标的机制：表观生物学。

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Epigenetic regulation of gene expression plays an important role in learning and memory, mediating the influence of experience on critical mechanisms of plasticity. Speakers in the opening session of the Summit reviewed research on epigenetic contributions to age-related cognitive decline and discussed strategies for the development of interventions targeting epigenetic mechanisms. The presentations focused on experience-dependent DNA methylation, the regulatory role of microRNAs, histone deacetylases as potential therapeutic targets, and strategies for exploring epigenetic contributions to the aging of brain and cognition. This session established useful mileposts for gaging progress in this rapidly advancing area of research.

机译：基因表达的表观遗传调节在学习和记忆中起着重要作用，调解了可塑性危重机制的影响。首脑会议开幕会议的发言者审查了对年龄相关认知下降的表观遗传贡献的研究，并讨论了针对表观遗传机制的干预措施的发展策略。介绍的介绍依赖于经验依赖性DNA甲基化，MicroRNA的调节作用，组蛋白脱乙酰化酶作为潜在的治疗目标，以及探索脑和认知老化的表观遗传贡献的策略。本次会议建立了有用的里程碑，以便在这次迅速推进的研究领域进行了学习进展。

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《The journals of gerontology.Series A. Biological sciences and medical sciences》 |2012年第7期|共6页
作者
Kenneth S Kosik; Peter R Rapp; Naftali Raz; Scott A Small; J David Sweatt; Li-Huei Tsai;
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Laboratory of Experimental Gerontology National Institute on Aging 251 Bayview Blvd Suite 100;

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正文语种 eng
中图分类老年病学;
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1. Mechanisms of age-related cognitive change and targets for intervention: epigenetics. [J] . Kenneth S Kosik, Peter R Rapp, Naftali Raz, The journals of gerontology.Series A. Biological sciences and medical sciences . 2012,第7期

机译：与年龄有关的认知变化的机制和干预目标：表观遗传学。
2. Session II: Mechanisms of Age-Related Cognitive Change and Targets for Intervention: Neural Circuits, Networks, and Plasticity. [J] . Charles Decarli, Claudia Kawas, John H Morrison, The journals of gerontology.Series A. Biological sciences and medical sciences . 2012,第7期

机译：第二节：与年龄有关的认知变化的机制和干预目标：神经回路，网络和可塑性。
3. Session III: Mechanisms of Age-Related Cognitive Change and Targets for Intervention: Inflammatory, Oxidative, and Metabolic Processes. [J] . Suzanne Craft, Thomas C Foster, Philip W Landfield, The journals of gerontology.Series A. Biological sciences and medical sciences . 2012,第7期

机译：第三节：与年龄有关的认知变化的机制和干预目标：炎症，氧化和代谢过程。
4. Change in Driving Behavior by Elderly (Second Report) - Analysis of Driving Behavior to Adapt to Age-related Changes of Cognitive and Physical Functions [C] . Toshihisa Sato, Motoyuki Akamatsu, Ayukoiwasaki, 自動車技術会大会 . 2006

机译：老年人的驾驶行为（第二次报告） - 驾驶行为分析，以适应认知和物理功能的年龄相关变化
5. Mechanisms underlying age-related cognitive decline and sensitivity to brain-derived neurotrophic factor. [D] . Merrill, David Arthur. 2002

机译：年龄相关的认知能力下降和对脑源性神经营养因子敏感性的潜在机制。
6. Mechanisms of Age-Related Cognitive Change and Targets for Intervention: Social Interactions and Stress [O] . William S. Kremen, Margie E. Lachman, Jens C. Pruessner, -1

机译：与年龄有关的认知变化机制和干预目标：社会互动和压力
7. Session III: Mechanisms of Age-Related Cognitive Change and Targets for Intervention: Inflammatory, Oxidative, and Metabolic Processes [O] . S. Craft, T. C. Foster, P. W. Landfield, 2012

机译：第三次会议：年龄相关的认知变化和干预目标的机制：炎症，氧化和代谢过程
8. Considerations for the Design of a Systemic Review of Interventions for Preventing Clinical Alzheimer’s-Type Dementia, Mild Cognitive Impairment, and Age-Related Cognitive Decline. Letter Report. [R] . 2015

机译：设计预防临床阿尔茨海默氏型痴呆，轻度认知障碍和年龄相关认知衰退的干预系统评价的考虑因素。信报告。

Mechanisms of age-related cognitive change and targets for intervention: epigenetics.

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