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首页> 外文期刊>The journals of gerontology.Series A. Biological sciences and medical sciences >Patterns of focal gray matter atrophy are associated with bradykinesia and gait disturbances in older adults.
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Patterns of focal gray matter atrophy are associated with bradykinesia and gait disturbances in older adults.

机译：局灶性灰质萎缩的模式与老年人的Bradykinesia和Gait紊乱有关。

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Identify the neuroimaging correlates of parkinsonian signs in older adults living in the community.Magnetic resonance imaging was obtained in 307 adults (82.9 years, 55% women, 39% blacks) concurrently with the Unified Parkinson Disease Rating scale-motor part. Magnetic resonance imaging measures included volume of whole-brain white matter hyperintensities and of gray matter for primary sensorimotor, supplementary motor, medial temporal areas, cerebellum, prefronto-parietal cortex, and basal ganglia.About 25% of the participants had bradykinesia, 26% had gait disturbances, and 12% had tremor. Compared with those without, adults with any one of these signs were older, walked more slowly, had worse scores on tests of cognition, mood and processing speed, and higher white matter hyperintensities volume (all p ≤ .002). Gray matter volume of primary sensorimotor area was associated with bradykinesia (standardized odds ratio [95% confidence interval]: 0.46 [0.31, 0.68], p < .0001), and gray matter volume of medial temporal area was associated with gait disturbances (0.56 [0.42, 0.83], p < .0001), independent of white matter hyperintensities volume and age. Further adjustment for measures of muscle strength, cardiovascular health factors, cognition, processing speed, and mood or for gait speed did not substantially change these results.Atrophy within primary sensorimotor and medial temporal areas might be important for development of bradykinesia and of gait disturbances in community-dwelling elderly adults. The pathways underlying these associations may not include changes in white matter hyperintensities volume, cognition, information processing speed, mood, or gait speed.
机译：确定生活在社区中的老年人的神经影像症的关联。在307名成人（82.9岁，55％女性，39％黑人）与统一的帕金森病评定鳞片电机部分同时获得磁共振成像。磁共振成像措施包括全脑白质的容量和原发性传感器的灰质，补充电机，内侧颞段区域，小脑，前晶胞皮层和基底神经节。25％的参与者有Bradykinesia，26％有步态的骚乱，12％的震颤。与那些没有任何这些迹象的成年人比较年长，走得更慢，在认知，情绪和加工速度的测试以及更高的白金高度体积（所有P≤.002）上更慢地走了得分。原发性传感器区域的灰质体积与Bradykinesia（标准化的差距[95％置信区间]：0.46 [0.31,0.68]，P <.0001），内侧时间区域的灰质体积与步态紊乱有关（0.56 [0.42,0.83]，p <.0001），独立于白质高萎缩体积和年龄。进一步调整肌肉力量，心血管健康因素，认知，加工速度和情绪或步态速度的措施并未大大改变这些结果。原发性传感器和中间时间区域内的养殖对Bradykinesia的发展可能是重要的社区住宅老年人。这些关联的途径可能不包括白质高度容积，认知，信息处理速度，情绪或步态速度的变化。

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