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首页> 外文期刊>The journals of gerontology.Series A. Biological sciences and medical sciences >SIRT1 Polymorphisms and Serum-Induced SIRT1 Protein Expression in Aging and Frailty: The CHAMP Study
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SIRT1 Polymorphisms and Serum-Induced SIRT1 Protein Expression in Aging and Frailty: The CHAMP Study

机译：SIRT1多态性和血清诱导的SIRT1衰老和脆弱的蛋白表达：冠军研究

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摘要

The nutrient sensing protein, SIRT1 influences aging and nutritional interventions such as caloric restriction in animals, however, the role of SIRT1 in human aging remains unclear. Here, the role of SIRT1 single-nucleotide polymorphisms (SNPs) and serum-induced SIRT1 protein expression (a novel assay that detects circulating factors that influence SIRT1 expression in vitro) were studied in the Concord Health and Ageing in Men Project (CHAMP), a prospective cohort of community dwelling men aged 70 years and older. Serum-induced SIRT1 expression was not associated with age or mortality, however participants within the lowest quintile were less likely to be frail (odds ratio (OR) 0.34, 95% confidence interval (CI) 0.17-0.69, N = 1,309). Serum-induced SIRT1 expression was associated with some markers of body composition and nutrition (height, weight, body fat and lean % mass, albumin, and cholesterol) but not disease. SIRT1 SNPs rs2273773, rs3740051, and rs3758391 showed no association with age, frailty, or mortality but were associated with weight, height, body fat and lean, and albumin levels. There were some weak associations between SIRT1 SNPs and arthritis, heart attack, deafness, and cognitive impairment. There was no association between SIRT1 SNPs and the serum-induced SIRT1 assay. SIRT1 SNPs and serum-induced SIRT1 expression in older men may be more closely associated with nutrition and body composition than aging and age-related conditions.
机译：营养传感蛋白，SIRT1影响动物的老化和营养干预（如动物的热量限制），然而，SIRT1在人类衰老中的作用仍不清楚。在此，在男性项目（CHAMP）中的康科德健康和老化中，研究了SIRT1单核苷酸多态性（SNP）和血清诱导的SIRT1蛋白表达（一种检测体外影响SIRT1表达的循环因子的新测定），一个70岁及以上的社区住宅的预期队列。血清诱导的SIRT1表达与年龄或死亡率无关，然而，最低五分素内的参与者不太可能是脆弱的（大量比（或）0.34,95％置信区间（CI）0.17-0.69，n = 1,309）。血清诱导的SIRT1表达与身体成分和营养的一些标记（高度，重量，体脂和稀质量质量，白蛋白和胆固醇）相关，但不是疾病。 SIRT1 SNPS RS2273773，RS3740051和RS3758391显示出与年龄，脆弱或死亡率无关，但与体重，身高，体脂和瘦，白蛋白水平有关。 SIRT1 SNP和关节炎，心脏病发作，耳聋和认知障碍有一些薄弱的关联。 SIRT1 SNP和血清诱导的SIRT1测定之间没有关联。 SIRT1 SNP和血清诱导的老年人的SIRT1表达可能与营养和身体组成相关的表达，而不是老化和年龄相关的条件。

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