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首页> 外文期刊>The journals of gerontology.Series A. Biological sciences and medical sciences >A Clinically Relevant Frailty Index for Aging Rats
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A Clinically Relevant Frailty Index for Aging Rats

机译：衰老大鼠临床相关的脆弱指数

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摘要

Frailty is a clinical syndrome that is increasingly prevalent during aging. Frailty involves the confluence of reduced strength, speed, physical activity, and endurance and is associated with adverse health outcomes. The present study adapts existing clinical and preclinical indices of frailty to the Fischer (F344) rat. Male F344 rats (n = 133; 17 mo) completed a battery of behavioral tasks, including forelimb wire suspension (strength), rotarod (speed), open field (physical activity), and inclined screen (endurance). Rats that performed poorly (lowest quintile) on two tasks were considered mildly frail (17.29%, n = 23), and rats that performed poorly on 3-4 tasks were considered frail (2.26%, n = 3). Logistic regression of 100-day survival revealed that mildly frail rats were 3.8 times and frail rats were 27.5 times more likely to die during that period than nonfrail rats (p =.038; 95% confidence interval: 2.030, 372.564). The selected criterion tests, cutoff points, and index provide a potential tool for identifying frailty in aged F344 rats, which is consistent with existing frailty indices for humans and mice.
机译：脆弱是一种临床综合症，在老龄化时越来越普遍。脆弱涉及减少强度，速度，身体活动和耐久性的汇合，并且与不良健康结果有关。目前的研究适应了Fischer（F344）大鼠的现有临床和临床前索引。雄性F344大鼠（n = 133; 17 mo）完成了一种行为任务的电池，包括前列线悬架（强度），旋钮（速度），开放场（物理活动）和倾斜屏幕（耐久性）。在两项任务中进行的大鼠（最低五分之一）被认为是温和的脆弱（17.29％，n = 23），并且在3-4个任务上表现不佳的大鼠被认为是脆弱的（2.26％，n = 3）。 100天存活的逻辑回归显示，在比非饲料大鼠（P = 0.038; 95％置信区间：2.030,372.564）中，轻微的脆性大鼠均为3.8倍，脆性大鼠的死亡率均为27.5倍。所选择的标准测试，截止点和索引提供了识别年龄F344大鼠的脆弱性的潜在工具，这与人类和小鼠的现有体外索引一致。

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