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首页> 外文期刊>The journals of gerontology.Series A. Biological sciences and medical sciences >Environmental Canalization of Life Span and Gene Expression in Caenorhabditis elegans
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Environmental Canalization of Life Span and Gene Expression in Caenorhabditis elegans

机译：秀丽隐杆线虫生命跨度和基因表达的环境泛化

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摘要

Animals, particularly poikilotherms, exhibit distinct physiologies at different environmental temperatures. Here, we hypothesized that temperature-based differences in physiology could affect the amount of variation in complex quantitative traits. Specifically, we examined, in Caenorhabditis elegans, how different temperatures (15 degrees C, 20 degrees C, and 25 degrees C) affected the amount of interindividual variation in life span and also expression of three reporter genes-transcriptional reporters for vit-2, gpd-2, and hsp-16.2 (a life-span biomarker). We found the expected inverse relationship between temperature and average life span. Surprisingly, we found that at the highest temperature, there were fewer differences between individuals in life span and less interindividual variation in expression of all three reporters. We suggest that growth at 25 degrees C might canalize (reduce interindividual differences in) life span and expression of some genes by eliciting a small constitutive heat shock response. Growth at 25 degrees C requires wild-type hsf-1, which encodes the main heat shock response transcriptional activator. We speculate that increased chaperone activity at 25 degrees C may reduce interindividual variation in gene expression by increasing protein folding efficiency. We hypothesize that reduced variation in gene expression may ultimately cause reduced variation in life span.
机译：动物，特别是Poikilotherms，在不同环境温度下表现出不同的生理学。在这里，我们假设生理学的基于温度的差异可能影响复杂定量性状的变化量。具体而言，我们检查了秀丽隐杆线虫，在Caenorhabditis，温度如何（15摄氏度，20摄氏度和25℃）影响寿命的中断变化的量，也为Vit-2的三个报告基因转录记者表达， GPD-2和HSP-16.2（寿命生物标志物）。我们发现温度与平均寿命之间的预期反转关系。令人惊讶的是，我们发现在最高温度下，人们在寿命中的个体之间存在较少的差异，并且在所有三个记者表达中的表达较少的中断变化。我们认为25摄氏度的增长可能会通过引发小的组成型热休克反应来计算（减少终身差异）生命跨度和一些基因的表达。 25摄氏度的生长需要野生型HSF-1，其编码主热休克响应转录激活物。推测，通过增加蛋白质折叠效率，推测25摄氏度的增加的伴侣活性可以减少基因表达的中断变化。我们假设降低基因表达的变化最终可能导致生命跨度的变化降低。

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