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首页> 外文期刊>The journals of gerontology.Series A. Biological sciences and medical sciences >The Effects of Graded Levels of Calorie Restriction: X. Transcriptomic Responses of Epididymal Adipose Tissue
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The Effects of Graded Levels of Calorie Restriction: X. Transcriptomic Responses of Epididymal Adipose Tissue

机译：渐变水平的卡路里限制水平的影响：X.附睾脂肪组织的转录组反应

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摘要

Calorie restriction (CR) leads to a remarkable decrease in adipose tissue mass and increases longevity in many taxa. Since the discovery of leptin, the secretory abilities of adipose tissue have gained prominence in the responses to CR. We quantified transcripts of epididymal white adipose tissue of male C57BL/6 mice exposed to graded levels of CR (0–40% CR) for 3 months. The numbers of differentially expressed genes (DEGs) involved in NF-κB, HIF1-α, and p53 signaling increased with increasing levels of CR. These pathways were all significantly downregulated at 40% CR relative to 12 h ad libitum feeding. In addition, graded CR had a substantial impact on DEGs associated with pathways involved in angiogenesis. Of the 497 genes differentially expressed with graded CR, 155 of these genes included a signal peptide motif. These putative signaling proteins were involved in the response to ketones, TGF-β signaling, negative regulation of insulin secretion, and inflammation. This accords with the previously established effects of graded CR on glucose homeostasis in the same mice. Overall these data suggest reduced levels of adipose tissue under CR may contribute to the protective impact of CR in multiple ways linked to changes in a large population of secreted proteins.
机译：卡路里限制（Cr）导致脂肪组织质量显着降低，并增加了许多分类群中的寿命。由于瘦素的发现，脂肪组织的分泌能力在对Cr的反应中获得了突出。我们将雄性C57BL / 6小鼠的附睾白色脂肪组织的转录物定量暴露于Cr（0-40％Cr）的分级水平3个月。参与NF-κB，HIF1-α和P53信号传导中涉及的差异表达基因（DEGS）的数量随着CR水平的增加而增加。这些途径在40％Cr中，相对于12小时可利用，所有途径都明显下调。此外，梯度Cr对与血管生成中涉及的途径相关的次数具有显着影响。在用梯度Cr差异表达的497个基因中，这些基因的155个包括信号肽基序。这些推定的信号蛋白涉及对酮，TGF-β信号传导，胰岛素分泌负调节和炎症的响应。这符合渐变Cr在同一小鼠中葡萄糖稳态的先前建立的效果。总体而言，这些数据表明CR下的脂肪组织水平降低可能有助于CR以多种方式有助于与大群分泌蛋白质的变化有贡献。

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