...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The journals of gerontology.Series A. Biological sciences and medical sciences >Sexual Dimorphism in the Behavioral Responses and the Immunoendocrine Status in d-Galactose-Induced Aging
【24h】

Sexual Dimorphism in the Behavioral Responses and the Immunoendocrine Status in d-Galactose-Induced Aging

机译：D-半乳糖诱导老化的行为反应和免疫分泌状态的性二态

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

For almost 20 years, chronic systemic d-galactose, a monosaccharide abundantly present in milk products, fruits, and vegetables, has been used as a tool to achieve models of accelerated aging. Its neurotoxicity, induced by abnormal accumulation of reactive oxygen species and advanced glycation end products, has been widely reported. However, behavioral outcomes are still controversial and little is known about sex-dependent vulnerability. We performed a comprehensive behavioral and multifunctional screening of the chronic effects of low (50 mg/kg) and high (100 mg/kg) doses of d-galactose in 6-month-old male and female gold-standard C57BL/6 mice. Twelve classical tests with convergent validity analyzed sensorimotor, emotional and cognitive domains, indicating the existence of thresholds of response. Distinct vulnerability patterns were found in a selective sex- and dose-dependent manner. In males, d-galactose induced sensorimotor impairment and immunoendocrine senescence, but the low dose resulted in improved learning and memory. Oppositely, d-galactose-treated females exhibited a dose-dependent worse motor and spatial learning, but improved memory. Behavioral outcome items point at distinct neuronal substrates underlying the functional capacity of d-galactose-treated animals to meet task-dependent performance demands. They support that males and females can be regarded as two exceptional natural scenarios to study the functional interplay in the cross talk of homeostatic networks in aging.
机译：近20年来，慢性全身D-半乳糖，大量出现在牛奶制品，水果和蔬菜中的单糖，已被用作实现加速老化模型的工具。其神经毒性是通过反应性氧物种的异常积累和先进的糖化末端产物诱导的神经毒性。然而，行为结果仍然存在争议，并且关于性依赖性脆弱性知之甚少。我们在6个月大的雄性和女性金标准C57BL / 6小鼠中对低（50mg / kg）和高（100mg / kg）剂量的D-半乳糖剂的慢性效应进行了全面的行为和多功能筛选。具有会聚有效性的十二个经典测试分析了感觉运动器，情绪和认知结构域，表示存在响应阈值。以选择性的性别和剂量依赖的方式发现了不同的漏洞模式。在雄性，D-半乳糖诱导的感觉运动障碍和免疫分泌衰老，但低剂量导致了改善的学习和记忆。相反，D-半乳糖处理的女性表现出一种剂量依赖性较差的电动机和空间学习，而是改善了记忆力。行为结果在D-半乳糖处理的动物功能能力下面的不同神经元底物中，以满足任务依赖性的性能需求。他们支持雄性和女性可以被视为两个特殊的自然情景，以研究谐静网络的跨谈中的功能相互作用。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号