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首页> 外文期刊>The journals of gerontology.Series A. Biological sciences and medical sciences >Longitudinal Muscle and Myocellular Changes in Community-Dwelling Men Over Two Decades of Successful Aging-The ULSAM Cohort Revisited
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Longitudinal Muscle and Myocellular Changes in Community-Dwelling Men Over Two Decades of Successful Aging-The ULSAM Cohort Revisited

机译：纵向肌肉和肌细胞变化在共同成功的老龄化两十年的成功衰老 - ulsam队列重新审议

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摘要

Participants of the population-based Uppsala longitudinal study of adult men (ULSAM) cohort reaching more than 88 years of age (survivors, S) were investigated at age 70, 82, and 88-90 and compared at 70 years with non-survivors (NS) not reaching 82 years. Body composition, muscle mass and muscle histology were remarkably stable over 18 years of advanced aging in S. Analysis of genes involved in muscle remodeling showed that S had higher mRNA levels of myogenic differentiation factors (Myogenin, MyoD), embryonic myosin (eMyHC), enzymes involved in regulated breakdown of myofibrillar proteins (Smad2, Trim32, MuRF1,) and NCAM compared with healthy adult men (n = 8). S also had higher mRNA levels of eMyHC, Smad 2, MuRF1 compared with NS. At 88 years, S expressed decreased levels of Myogenin, MyoD, eMyHC, NCAM and Smad2 towards those seen in NS at 70 years. The gene expression pattern of S at 70 years was likely beneficial since they maintained muscle fiber histology and appendicular lean body mass until advanced age. The expression pattern at 88 years may indicate a diminished muscle remodeling coherent with a decline of reinnervation capacity and/or plasticity at advanced age.
机译：在70,82和88-90岁的70,82,88-90岁时调查了成年男性（ULSAM）群体（Ulsam）队达到88岁以上的人口纵向研究的参与者，并在70年与非幸存者（ ns）没有达到82年。身体成分，肌肉质量和肌肉组织学在18岁以上的S.肌肉重塑中的基因分析显示出显着稳定，表明S具有更高的MRNA水平的肌遗传分化因子（Myogenin，Myod），胚胎肌蛋白（EmyHC），与健康成年男性（n = 8）相比，涉及肌原纤维蛋白（Smad2，Trim32，Murf1，）和Ncam的调节粒度（smad2，trim32，murf1，）和ncam。与NS相比，S还具有更高的MRNA水平，Smad 2，Murf1。 88年来，S表达了肌原素，Myod，emyhc，NCAM和Smad2的水平，朝70年来在NS中看到的那些。 70年来S的基因表达模式可能有益，因为它们保持肌纤维组织学和阑尾瘦体重直至晚期。 88岁时的表达模式可以表明肌肉重塑连贯的肌肉重塑连贯，在晚期的再生能力和/或可塑性下降。

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