...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The journals of gerontology.Series A. Biological sciences and medical sciences >Age-Related Differences in the Gut Microbiome of Rhesus Macaques
【24h】

Age-Related Differences in the Gut Microbiome of Rhesus Macaques

机译：恒河猴肠道肠道微生物组的年龄相关差异

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Aging is a multifactorial process characterized by progressive changes in gut physiology and the intestinal mucosal immune system. These changes, along with alterations in lifestyle, diet, nutrition, inflammation and immune function alter both composition and stability of the gut microbiota. Given the impact of environmental influences on the gut microbiota, animal models are particularly useful in this field. To understand the relationship between the gut microbiota and aging in nonhuman primates, we collected fecal samples from 20 male and 20 female rhesus macaques (Macaca mulatta), across the natural macaque age range, for 16S rRNA gene analyses. Operational taxonomic units were then grouped together to summarize taxon abundance at different hierarchical levels of classification and alpha- and beta-diversity were calculated. There were no age or sex differences in alpha diversity. At the phylum level, relative abundance of Proteobacteria and Firmicutes and Firmicutes to Bacteriodetes ratio were different between age groups though significance disappeared after correction for multiple comparisons. At the class level, relative abundance of Firmicutes_Bacilli decreased and Proteobacteria_Alphaproteobacteria and Proteobacteria_Betaproteobacteria increased with each successively older group. Only differences in Firmicutes_Bacilli remained significant after correction for multiple comparisons. No sex differences were identified in relative abundances after correction for multiple comparisons. Our results are not surprising given the known impact of environmental factors on the gut microbiota.
机译：老化是一种多因素过程，其特征是肠道生理学和肠粘膜免疫系统的逐步变化。这些变化以及生活方式，饮食，营养，炎症和免疫功能的改变改变了肠道微生物的组成和稳定性。鉴于环境影响对肠道微生物群的影响，动物模型在该领域特别有用。为了了解肠道​​微生物群和非人的衰老之间的关系，我们将粪便样本从20只雄性和20个雌性恒河猴（Macaca Mulatta），在天然猕猴范围内收集了16S rRNA基因分析的粪便样本。然后将运营分类单位组合在一起，总结分类乐队在不同分层水平的分类水平和α-和β多样性。 alpha多样性没有年龄或性别差异。在门水平下，年龄组之间的植物菌和压制和对细菌的相对丰度以及对嗜菌的比例不同，但在多重比较后显着消失，仍然存在显着性。在阶级水平上，对_Bacilli的相对丰度降低，植物蛋白酶蛋白和蛋白酶癌和蛋白酶_Betaproteobacteria随着每个先后较旧的群体增加。在多重比较校正后，刚刚_Bacilli的差异仍然显着。在纠正多重比较后，在相对丰富的情况下没有确定性别差异。鉴于环境因素对肠道微生物群的已知影响，我们的结果并不令人惊讶。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号