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首页> 外文期刊>The journals of gerontology.Series A. Biological sciences and medical sciences >Transgenerational Obesity and Healthy Aging in Drosophila
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Transgenerational Obesity and Healthy Aging in Drosophila

机译：果蝇在果蝇的转基因肥胖和健康老龄化

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摘要

Substantial evidence suggests that individuals born to overweight and obese parents suffer detrimental health consequences that dramatically decrease healthy aging. The number of obese individuals worldwide now exceeds the number of under- and malnourished individuals. This obesity epidemic is responsible for approximately 4 million deaths worldwide each year, and predisposes sufferers to a range of age-related diseases such as cardiovascular diseases, and metabolic syndrome. Additionally, obesity is associated with an accelerated onset of age-related ailments, such as cancers and inflammation. The importance of dietary interventions to reduce the incidence of obesity is magnified by emerging evidence that parental physiology can predispose future generations to poor health outcomes. Characterizing and understanding these effects, and how they are mediated, is important if we are to continue to drive improvements to population health. In this article, we synthesize evidence for the intergenerational and transgenerational phenotypic effects of parental obesity. We concentrate on how the fruit fly Drosophila melanogaster can be used as a model to study these effects. Fruit flies are highly tractable, and their conserved nutrient signaling and metabolic pathways make them an ideal model for studying nutritional effects on metabolic, reproductive, and aging phenotypes.
机译：实质性证据表明，出生于超重和肥胖父母的个人遭受严重减少健康老化的有害健康后果。全世界肥胖个体的数量现在超过营养不良的人数。这种肥胖疫情每年负责全世界约有400万人死亡，并倾向于患者与心血管疾病等一系列相关的疾病和代谢综合征。此外，肥胖与年龄相关的疾病的加速发作相关，例如癌症和炎症。饮食干预减少肥胖症的重要性通过新出现的证据来放大，即父母生理可以将后代倾向于贫困的健康结果。表征和理解这些效果，以及它们如何调解，如果我们继续推动人口健康的改进，是重要的。在本文中，我们综合了父母肥胖的代际和转基因表型作用的证据。我们专注于水果蝇果蝇Melanogaster如何用作研究这些效果的模型。果蝇是高度易行的，其保守的营养信令和代谢途径使它们成为研究代谢，生殖和老化表型研究营养作用的理想模型。

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