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首页> 外文期刊>The journals of gerontology.Series A. Biological sciences and medical sciences >A Systematic Review and Meta-analysis of Environmental, Lifestyle, and Health Factors Associated With DNA Methylation Age
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A Systematic Review and Meta-analysis of Environmental, Lifestyle, and Health Factors Associated With DNA Methylation Age

机译：对与DNA甲基化年龄相关的环境，生活方式和健康因子进行系统审查和荟萃分析

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摘要

DNA methylation (DNAm) algorithms of biological age provide a robust estimate of an individual's chronological age and can predict their risk of age-related disease and mortality. This study reviewed the evidence that environmental, lifestyle and health factors are associated with the Horvath and Hannum epigenetic clocks. A systematic search identified 61 studies. Chronological age was correlated with DNAm age in blood (median .83, range .13-.99). In a meta-analysis body mass index (BMI) was associated with increased DNAm age (Hannum beta: 0.07, 95% CI 0.04 to 0.10; Horvath beta: 0.06, 95% CI 0.02 to 0.10), but there was no association with smoking (Hannum beta: 0.12, 95% CI -0.50 to 0.73; Horvath beta:0.18, 95% CI -0.10 to 0.46). DNAm age was positively associated with frailty (three studies, n = 3,093), and education was negatively associated with the Hannum estimate of DNAm age specifically (four studies, n = 13,955). For most other exposures, findings were too inconsistent to draw conclusions. In conclusion, BMI was positively associated with biological aging measured using DNAm, with some evidence that frailty also increased aging. More research is needed to provide conclusive evidence regarding other exposures. This field of research has the potential to provide further insights into how to promote slower biological aging and ultimately prolong healthy life.
机译：DNA甲基化（Dnam）生物年龄算法提供了对个体的年龄年龄的稳健估计，可以预测其与年龄相关疾病和死亡率的风险。本研究综述了有证据表明，环境，生活方式和健康因素与Horvath和Hannum表观遗传时钟相关。系统搜索确定了61项研究。时间年龄与血液中的Dnam年龄相关（中位数.83，范围.13-.99）。在Meta分析体重指数（BMI）中与DNAM年龄（Hannum Beta：0.07,95％CI 0.04至0.10; 0.06,95％CI 0.02至0.10）相关，但与吸烟无关（Hannum Beta：0.12,95％CI -0.50至0.73; Horvath Beta：0.18,95％CI -0.10至0.46）。 Dnam年龄与脆弱（三项研究，N = 3,093）呈正相关（N = 3,093），教育与Dnam年龄的Hannum估计有关（四项研究，N = 13,955）。对于大多数其他曝光，调查结果过于不一致，无法得出结论。总之，BMI与使用DNAM测量的生物学衰老呈正相关，有一些证据表明脆弱的老化也增加了。需要更多的研究来提供关于其他暴露的确凿证据。该研究领域有可能为如何促进生物老化和最终延长健康生活提供进一步的见解。

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