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首页> 外文期刊>The journals of gerontology.Series A. Biological sciences and medical sciences >Klotho: An Elephant in Aging Research
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Klotho: An Elephant in Aging Research

机译：Klotho：老化研究中的大象

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The year 2017 marked the 20th anniversary of the first publication describing Klotho. This single protein was and is remarkable in that its absence in mice conferred an accelerated aging, or progeroid, phenotype with a dramatically shortened life span. On the other hand, genetic overexpression extended both health span and life span by an impressive 30%. Not only has Klotho deficiency been linked to a number of debilitating age-related illnesses but many subsequent reports have lent credence to the idea that Klotho can compress the period of morbidity and extend the life span of both model organisms and humans. This suggests that Klotho functions as an integrator of organ systems, making it both a promising tool for advancing our understanding of the biology of aging and an intriguing target for interventional studies. In this review, we highlight advances in our understanding of Klotho as well as key challenges that have somewhat limited our view, and thus translational potential, of this potent protein.
机译：2017年，标志着第一个出版物的20周年描述了Klotho。这种单一的蛋白质是显着的，因为它在小鼠中不存在赋予加速的老化或葡萄甾醇，具有显着缩短的寿命的表型。另一方面，遗传过度表达延伸了健康跨度和寿命，令人印象深刻的30％。 Klotho缺乏与许多与衰弱的年龄相关的疾病有关，但许多后续报告都借给了Klotho可以压缩发病率的想法并延长模型生物和人类的寿命。这表明Klotho用作器官系统的积分器，使其成为推进我们对衰老生物学的理解和介入研究的有趣目标的有希望的工具。在这篇综述中，我们突出了我们对Klotho的理解的进步，以及这种有效蛋白的观点和因此平移潜力的关键挑战。

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