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首页> 外文期刊>The journals of gerontology.Series A. Biological sciences and medical sciences >Moderating Effect of White Matter Integrity on Brain Activation During Dual-Task Walking in Older Adults
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Moderating Effect of White Matter Integrity on Brain Activation During Dual-Task Walking in Older Adults

机译：白质完整对老年人双重任务脑激活的调节效果

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Using multimodal neuroimaging methods, the current study was designed to examine the relationship between white matter microstructural integrity (WMI) and changes in prefrontal cortex (PFC) oxygenated hemoglobin (HbO(2)) during active walking in older adults. Consistent with neural inefficiency, we hypothesized that worse WMI would be associated with a greater increase in PFC HbO(2) from single to dual-task walking in the context of worse or similar gait performance. Fifty-five cognitively healthy older adults (mean age = 74.76 years, 49% women) underwent diffusion tensor imaging (DTI) to derive a whole-brain measure of fractional anisotropy (FA) and functional Near Infrared Spectroscopy (fNIRS), which measured PFC HbO(2) during walking tasks. Gait velocity was assessed using an instrumented walkway. A linear mixed effects model revealed that HbO(2) levels increased from single to dual-task walking (P < 0.01) given the greater cognitive demands inherent in the latter condition. Moreover, WMI moderated the effect of dual tasking on PFC HbO(2) (P < 0.05). Specifically, worse WMI was associated with a larger increase in PFC HbO(2) levels from single to dual-task walking in the context of similar gait velocity. Results suggest that compromised WMI may be a mechanism underlying inefficient brain response to cognitive demands of locomotion.
机译：使用多模式神经影像疗法方法，设计目前的研究以检查白质微结构完整性（WMI）与前额叶皮质（PFC）含氧血红蛋白（HBO（2））的变化在老年人的情况下的关系。与神经效率效率一致，我们假设从单曲到双重任务的PFC HBO（2）较差的WMI在更糟糕或类似的步态表现的情况下，WMI更差。五十五名认知健康的老年人（平均年龄= 74.76岁，49％的女性）接受了扩散张量成像（DTI）来得出分数各向异性（FA）和功能靠近红外光谱（FNIR）的全脑衡量标准PFC HBO（2）在步行任务期间。使用仪表式人行道评估步态速度。鉴于后者条件中固有的更大认知需求，HBO（2）水平从单一到双任务步行增加（P <0.01）。此外，WMI调节双任务对PFC HBO（2）的影响（P <0.05）。具体而言，在类似的步态速度的背景下，WMI与单个到双任务的PFC HBO（2）水平的较大增加有关。结果表明，损害的WMI可能是对效率低下脑响应的机制，以对运动的认知需求。

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