Safety and immunogenicity of the novel tuberculosis vaccine ID93+GLA-SE in BCG-vaccinated healthy adults in South Africa: a randomised, double-blind, placebo-controlled phase 1 trial

Penn-Nicholson Adam; Tameris Michele; Smit Erica; Day Tracey A.; Musvosvi Munyaradzi; Jayashankar Lakshmi; Vergara Julie; Mabwe Simbarashe; Bilek Nicole; Geldenhuys Hendrik; Luabeya Angelique Kany-Kany; Ellis Ruth; Ginsberg Ann M.; Hanekom Willem A.; Reed Steven G.; Coler Rhea N.; Scriba Thomas J.; Hatherill Mark

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Safety and immunogenicity of the novel tuberculosis vaccine ID93+GLA-SE in BCG-vaccinated healthy adults in South Africa: a randomised, double-blind, placebo-controlled phase 1 trial

机译：新型结核病疫苗ID93 + GLA-SE的安全性和免疫原性在南非的BCG接种的健康成人中：随机，双盲，安慰剂控制阶段1试验

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Background A vaccine that prevents pulmonary tuberculosis in adults is needed to halt transmission in endemic regions. This trial aimed to assess the safety and immunogenicity of three administrations at varying doses of antigen and adjuvant of an investigational vaccine (ID93 + GLA-SE) compared with placebo in previously BCG-vaccinated healthy adults in a tuberculosis endemic country.

机译：背景技术需要预防成人肺结核的疫苗在流行区域中停止传播。该试验旨在评估三种施用的三种施用的安全性和免疫原性，以及在结核人群国家的先前BCG接种的健康成年人中与安慰剂的调查疫苗（ID93 + GLA-SE）的辅助和佐剂。

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《The lancet. Respiratory medicine.》 |2018年第4期|共12页
作者
Penn-Nicholson Adam; Tameris Michele; Smit Erica; Day Tracey A.; Musvosvi Munyaradzi; Jayashankar Lakshmi; Vergara Julie; Mabwe Simbarashe; Bilek Nicole; Geldenhuys Hendrik; Luabeya Angelique Kany-Kany; Ellis Ruth; Ginsberg Ann M.; Hanekom Willem A.; Reed Steven G.; Coler Rhea N.; Scriba Thomas J.; Hatherill Mark;
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作者单位

Univ Cape Town Inst Infect Dis &

Mol Med SATVI Cape Town South Africa;

Univ Cape Town Inst Infect Dis &

Mol Med SATVI Cape Town South Africa;

Univ Cape Town Inst Infect Dis &

Mol Med SATVI Cape Town South Africa;

Infect Dis Res Inst Seattle WA USA;

Univ Cape Town Inst Infect Dis &

Mol Med SATVI Cape Town South Africa;

Infect Dis Res Inst Seattle WA USA;

Infect Dis Res Inst Seattle WA USA;

Univ Cape Town Inst Infect Dis &

Mol Med SATVI Cape Town South Africa;

Univ Cape Town Inst Infect Dis &

Mol Med SATVI Cape Town South Africa;

Univ Cape Town Inst Infect Dis &

Mol Med SATVI Cape Town South Africa;

Univ Cape Town Inst Infect Dis &

Mol Med SATVI Cape Town South Africa;

Aeras Rockville MD USA;

Aeras Rockville MD USA;

Univ Cape Town Inst Infect Dis &

Mol Med SATVI Cape Town South Africa;

Infect Dis Res Inst Seattle WA USA;

Infect Dis Res Inst Seattle WA USA;

Univ Cape Town Inst Infect Dis &

Mol Med SATVI Cape Town South Africa;

Univ Cape Town Inst Infect Dis &

Mol Med SATVI Cape Town South Africa;

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正文语种 eng
中图分类呼吸系及胸部疾病;
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1. Safety and immunogenicity of the novel tuberculosis vaccine ID93+GLA-SE in BCG-vaccinated healthy adults in South Africa: a randomised, double-blind, placebo-controlled phase 1 trial [J] . Penn-Nicholson Adam, Tameris Michele, Smit Erica, The lancet. Respiratory medicine. . 2018,第4期

机译：新型结核病疫苗ID93 + GLA-SE的安全性和免疫原性在南非的BCG接种的健康成人中：随机，双盲，安慰剂控制阶段1试验
2. Safety and immunogenicity of a recombinant adenovirus type-5 vector-based Ebola vaccine in healthy adults in Sierra Leone: a single-centre, randomised, double-blind, placebo-controlled, phase 2 trial [J] . Zhu Feng-Cai, Wurie Alie H., Hou Li-Hua, The Lancet . 2017,第10069期

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3. Safety and immunogenicity of a novel recombinant adenovirus type-5 vector-based Ebola vaccine in healthy adults in China: preliminary report of a randomised, double-blind, placebo-controlled, phase 1 trial [J] . Zhu Feng-Cai, Hou Li-Hua, Li Jing-Xin, The Lancet . 2015,第9984期

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6. Safety immunogenicity and efficacy of the candidate tuberculosis vaccine MVA85A in healthy adults infected with HIV-1: a randomised placebo-controlled phase 2 trial [O] . Birahim Pierre Ndiaye, Friedrich Thienemann, Martin Ota, -1

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Safety and immunogenicity of the novel tuberculosis vaccine ID93+GLA-SE in BCG-vaccinated healthy adults in South Africa: a randomised, double-blind, placebo-controlled phase 1 trial

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