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首页> 外文期刊>The American Journal of Cardiology >Effect on Mortality of Higher Versus Lower β-Blocker (Metoprolol Succinate or Carvedilol) Dose in Patients With Heart Failure
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Effect on Mortality of Higher Versus Lower β-Blocker (Metoprolol Succinate or Carvedilol) Dose in Patients With Heart Failure

机译：对心力衰竭患者的高等β-嵌体（美托洛尔琥珀酸盐或Carvedilol）剂量的影响影响

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This study aimed to compare the effect of β-blocker dose and heart rate (HR) on mortality in patients with heart failure with reduced ejection fraction (HFrEF). The Veteran Affairs databases were queried to identify all patients diagnosed with HFrEF based on International Classification of Diseases Ninth Revision codes from 2007 to 2015 and β-blocker (carvedilol or metoprolol succinate) use. 36,168 patients on low dose β blocker were then matched with 36,168 patients on high dose β-blocker using propensity score matching. The impact of β-blocker dose and HR was assessed on overall mortality using Cox proportional hazard model. After dividing average HR into separate quartiles and adjusting for patient characteristics, high β-blocker dose was associated with lower overall mortality as compared with a low dose of β blocker (hazard ratio 0.75, 95% confidence interval 0.73 to 0.77, p <0.01) independent of the HR achieved. The results held for all 4 quartiles of average HR. A higher β-blocker dose or a lower HR were independently and jointly associated with lower mortality for all quartiles of HR. In conclusion, higher dose of β-blocker therapy and a lower achieved HR were independently associated with a reduction in mortality in HFrEF patients.
机译：本研究旨在比较β-resser剂量和心率（HR）对心力衰竭患者的死亡率的比较，射血分数降低（HFREF）。询问资深事务数据库鉴定基于2007年至2015年至2015年的疾病第九修订代码的国际分类，识别诊断患有HFREF的患者，并从2007年到2015年和β-obleter（Carvedilol或MetoPolol琥珀酸盐）使用。 36,168例低剂量β受体阻滞患者随着36,168名高剂量β-阻滞剂患者使用倾向得分匹配匹配。使用Cox比例危害模型对β-resser剂量和HR的影响进行了评估了整体死亡率。将平均的HR分成单独的四分位数并调节患者特征后，与低剂量的β受体（危险比0.75,95％置信区间0.73至0.77，P <0.01）相比，高β-嵌体剂量与较低的整体死亡率相关。独立于人力资源达到。结果为所有4个平均人力资源患者持有。较高的β-嵌体剂量或较低的HR独立地，与所有HR的所有四分位数较低的死亡率相关联。总之，较高剂量的β-嵌体治疗和较低的达到的人力资源与HFRef患者的死亡率降低独立相关。

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