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首页> 外文期刊>The American Journal of Cardiology >Acute Effect of Hookah Smoking on Arterial Stiffness and Wave Reflections in Adults Aged 18 to 34 Years of Age
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Acute Effect of Hookah Smoking on Arterial Stiffness and Wave Reflections in Adults Aged 18 to 34 Years of Age

机译：18至34岁的成人动脉僵硬和波浪反射的急性作用

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摘要

Hookah (waterpipe) smoking is rapidly increasing in popularity worldwide. Despite being heavily advertised in the media as a healthier alternative to cigarettes, the toxicology of hookah smoke suggest otherwise. Cigarette smoking unequivocally causes an acute increase in arterial stiffness, but whether hookah does the same is unknown. In 48 young healthy habitual hookah but not cigarette smokers, we measured heart rate, peripheral and central blood pressure, carotid-femoral pulse wave velocity (measure of arterial stiffness), aortic augmentation index (measure of wave reflection), plasma nicotine, and exhaled carbon monoxide before and after ad lib hookah smoking. Hookah smoking increased heart rate by +16 ± 1 beats/min and mean brachial arterial pressure by +6 ± 1 mm Hg (both p <0.05, mean ± SE). Most importantly, it increased carotid-femoral pulse wave velocity and aortic augmentation index by +0.66 ± 0.09 m/s?1and +8.76 ± 3.99%, respectively (p <0.05, mean ± SE), denoting increased acute arterial stiffness. These vascular effects were accompanied by increases in plasma nicotine concentration (+5.8 ± 1.2 ng/ml, p <0.05) and expired carbon monoxide (+25.44 ± 1.68 ppm, p <0.05). All these parameters were unchanged during time-control studies (n?=?14). Thus, in contrast to effective media marketing of hookah as a safer alternative to cigarettes, the present study shows for the first time that in young adult hookah smokers, a single hookah smoking session causes an acute increase in arterial stiffness of comparable magnitude to what has been previously reported for cigarettes. Further research is warranted to determine whether habitual hookah smoking accelerates the age-dependent development of hypertension and its cardiovascular complications.
机译：水烟（水管）吸烟在全球普及中迅速增加。尽管在媒体中被宣传为健康的卷烟替代品，但烟雾的毒理学否则表现出来。吸烟毫不含糊地引起动脉僵硬的急性增加，但水烟是否与之相同。在48个年轻健康习惯水烟中，但没有吸烟者，我们测量了心率，周围和中枢血压，颈动脉股脉搏波速度（动脉刚度的测量），主动脉增强指数（波浪反射测量），血浆尼古丁和呼出在AD Lib Hookah吸烟之前和之后的一氧化碳。水烟筒吸烟的心率达到+ 16±1搏动/分钟/分钟，平均肱动脉压力+6±1 mm Hg（P <0.05，平均±SE）。最重要的是，它将颈动脉慢脉搏波速度和主动脉增强指数增加+ 0.66±0.09 m / s？1和+8.76±3.99％（P <0.05，平均值±SE），表示增加急性动脉僵硬度。这些血管作用伴随着血浆尼古丁浓度的增加（+ 5.8±1.2ng / ml，p <0.05）和过期的一氧化碳（+ 25.44±1.68 ppm，p <0.05）。在时间控制研究期间，所有这些参数都没有变化（n？=？14）。因此，与水烟的有效媒体营销相比，作为对卷烟的更安全的替代品，目前的研究表明，在年轻的成年水烟吸烟者中首次表现出一个烟熏烟囱吸烟者，导致动脉僵硬度的急性增加与具有的动脉僵硬以前报道香烟。有必要进一步研究，以确定习惯性水痘是否吸烟加速了高血压的年龄依赖性发展及其心血管并发症。

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