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首页> 外文期刊>The American Journal of Cardiology >Usefulness of high-sensitivity C-reactive protein to predict mortality in patients with atrial fibrillation (from the Atherosclerosis Risk in Communities [ARIC] study)
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Usefulness of high-sensitivity C-reactive protein to predict mortality in patients with atrial fibrillation (from the Atherosclerosis Risk in Communities [ARIC] study)

机译：高敏感性C反应蛋白预测心房颤动患者死亡率的有用性（来自社区的动脉粥样硬化风险[ARIC]研究）

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摘要

High-sensitivity C-reactive protein (hs-CRP) is a marker for the risk of cardiovascular and overall mortality. However, information about the association between hs-CRP and mortality in patients with atrial fibrillation is scarce. A total of 293 participants of the Atherosclerosis Risk In Communities study with a history of AF and hs-CRP levels available were studied. During a median follow-up of 9.4 years, 134 participants died (46%). The hazard ratio of all-cause mortality associated with the highest versus the lowest tertile of hs-CRP was 2.52 (95% confidence interval 1.49 to 4.25) after adjusting for age, gender, history of cardiovascular diseases, and cardiovascular risk factors. A similar trend was observed for cardiovascular mortality (57 events; hazard ratio 1.90, 95% confidence interval 0.81 to 4.45). The Congestive heart failure, Hypertension, Age >75 years, Diabetes, and previous Stroke or transient ischemic attack (CHADS2) score was also associated with all-cause and cardiovascular mortality, with an adjusted hazard ratio of 3.39 (95% confidence interval 1.91 to 6.01) and 8.71 (95% confidence interval 2.98 to 25.47), respectively, comparing those with a CHADS2 score >2 versus a CHADS2 score of 0. Adding hs-CRP to a predictive model including the CHADS2 score was associated with an improvement of the C-statistic for total mortality (from 0.627 to 0.677) and for cardiovascular mortality (from 0.700 to 0.718). In conclusion, high levels of hs-CRP constitute an independent marker for the risk of mortality in patients with atrial fibrillation.
机译：高敏感性C-反应蛋白（HS-CRP）是用于心血管和整体死亡率风险的标志物。然而，关于心房颤动患者HS-CRP和死亡率之间的关联的信息是稀缺的。研究了与AF和HS-CRP水平历史的社区研究中的动脉粥样硬化风险共293名参与者进行了研究。在9.4年的中位随访期间，134名参与者死亡（46％）。在调整年龄，性别，心血管疾病和心血管危险因素和心血管危险因素的年龄，性别，历史和心血管危险因素时，全导致的死亡率与最高的HS-CRP的死亡率的危害比率为2.52（95％置信区间1.49至4.25）。观察到具有类似趋势的心血管死亡率（57个事件;危险比1.90,95％置信区间0.81至4.45）。充血性心力衰竭，高血压，年龄> 75岁，糖尿病和先前的中风或短暂的缺血性发作（ChADS2）得分也与全因和心血管死亡率有关，调整后的危险比为3.39（95％置信区间1.91 6.01）和8.71（95％置信区间2.98至25.47）分别比较了乍得2分的乍得分数> 2与CHADS2得分为0.向包括CHADS2得分的预测模型添加HS-CRP与改进相关总死亡率（0.627至0.677）和心血管死亡率（0.700至0.718）的C统计。总之，高水平的HS-CRP构成了心房颤动患者死亡率的独立标志物。

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    HermidaJ.; LopezF.L.; MontesR.; MatsushitaK.; AstorB.C.; AlonsoA.;

  • 作者单位

    Division of Cardiovascular Sciences Center for Applied Medical Research University of Navarra;

    Division of Epidemiology and Community Health University of Minnesota School of Public Health;

    Division of Cardiovascular Sciences Center for Applied Medical Research University of Navarra;

    Division of Epidemiology Johns Hopkins Bloomberg School of Public Health Baltimore MD United;

    Division of Epidemiology Johns Hopkins Bloomberg School of Public Health Baltimore MD United;

    Division of Epidemiology and Community Health University of Minnesota School of Public Health;

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  • 正文语种 eng
  • 中图分类 心脏、血管（循环系）疾病;
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