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首页> 外文期刊>The American Journal of Cardiology >Relation of the Brugada Phenocopy to Hyperkalemia (from the International Registry on Brugada Phenocopy)
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Relation of the Brugada Phenocopy to Hyperkalemia (from the International Registry on Brugada Phenocopy)

机译：Brugada Fenacopy对高钾血症的关系（来自Brugada Falbocopy的国际登记处）

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摘要

Brugada phenocopies (BrPs) are clinical entities that differ in etiology from true congenital Brugada syndrome but have identical electrocardiographic (ECG) patterns. Hyperkalemia is known to be one of the causes of BrP. The aim of this study was to determine the clinical characteristics and evolution of hyperkalemia-induced BrP. Data from 27 cases of hyperkalemia-induced BrP were collected from the International Registry at www.brugadaphenocopy.com. Data were extracted from publications. Of the 27 patients included in the analysis, 18 (67%) were male; mean age was 53 15 years (range 31 to 89). Mean serum potassium concentration was 7.45 +/- 0.89 mmol/L. Type-1 Brugada ECG pattern was observed in 21 cases (78%), whereas 6 cases (22%) showed a type-2 Brugada ECG pattern. The Brugada ECG pattern resolved once the hyperkalemia was corrected, with no arrhythmic events. Estimated time to resolution was 7 +/- 3 hours. In 4 cases (16%), a concurrent metabolic abnormality was detected: 3 (11%) presented with acidosis, 2 (7%) with hyponatremia, 1 (4%) with hypocalcaemia, 1 (4%) with hyperphosphatemia, and 1 (4%) with hyperglycemia. In 7 cases (26%), provocative testing using sodium channel blockers was performed, and all failed to reproduce a BrS ECG pattern (BrP class A). Additionally, no sudden cardiac death or malignant ventricular arrhythmias were detected. Hyperkalemia was found a common cause of BrP in our International Registry. The Brugada ECG pattern appears to occur at high serum potassium concentrations (6.5 mmol/L). The ECG normalizes within hours of correcting the electrolyte imbalance. Importantly, hyperkalemiainduced BrP has not been associated with sudden cardiac death or ventricular arrhythmia. (C) 2017 Elsevier Inc. All rights reserved.
机译：Brugada Phanocopies（BRPS）是来自真正先天性的Brugada综合征的病因，但具有相同的心电图（ECG）图案的临床实体。已知高钾血症是BRP的原因之一。本研究的目的是确定高钾血症诱导的BRP的临床特征和演化。从Www.brudadaphenococcy.com的国际登记处收集27例高钾血症诱导的BRP的数据。数据从出版物中提取。在分析中包含的27名患者中，18名（67％）是男性;平均年龄为53 15岁（31至89分）。平均血清钾浓度为7.45 +/- 0.89 mmol / L.在21例（78％）中观察到Brugada ECG模式，而6例（22％）显示出2型Brugada ECG图案。一旦纠正高钾血症，就可以解决Brugada ECG模式，没有心律失常事件。预计分辨率的时间为7 +/- 3小时。在4例（16％）中，检测到同时的代谢异常：3（11％）呈现出酸中毒，2（7％）的低血症，1（4％），低钙血症，1（4％），高磷血症和1 （4％）具有高血糖症。在7例（26％）中，进行使用钠通道阻滞剂的挑衅性测试，并且都未能再现BRS ECG模式（BRP A类）。此外，未检测到突发的心脏死亡或恶性心律失常。高钾血症在我们的国际登记处发现了BRP的常见原因。 Brugada ECG图案似乎发生在高血清钾浓度（＆ 6.5mmol / L）。 ECG在校正电解质不平衡的时间内归一成。重要的是，Hyperkalemia诱导的BRP没有与突发的心脏死亡或心间心律失常有关。 （c）2017年Elsevier Inc.保留所有权利。

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