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首页> 外文期刊>The American journal of drug and alcohol abuse >Region-specific expression of precursor and mature brain-derived neurotrophic factors after chronic alcohol exposure
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Region-specific expression of precursor and mature brain-derived neurotrophic factors after chronic alcohol exposure

机译：慢性酒精暴露后的前体和成熟脑源性神经营养因子的区域特异性表达

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摘要

Background: Alcohol abuse is a serious health problem worldwide that causes a variety of physical and mental disorders. Research has shown that the brain-derived neurotrophic factor (BDNF) plays an important role in alcohol addiction. The BDNF precursor (proBDNF) exhibits different actions than BDNF through separate receptors and pathways in the central nervous system. However, the effects of proBDNF and BDNF in alcohol addiction are not fully known. Objectives: The objective was to identify the expression patterns and effects of proBDNF and BDNF after chronic alcohol exposure. Methods: A total of 40 male adult mice were studied. A mouse psychomotor sensitization (PS) model was established to explore the effects of BDNF and proBDNF treatment following chronic alcohol exposure. Reverse transcription PCR (RT-PCR) was performed to measure mRNA levels for BDNF, TrkB, P75NTR, and sortilin in the prefrontal cortex, hippocampus, and dorsal striatum of Kunming mice after chronic alcohol exposure. Results: In Kunming mice, chronic alcohol exposure up-regulated BDNF and TrkB mRNA levels in the prefrontal cortex, but decreased sortilin and P75 mRNA levels in the dorsal striatum. No changes in mRNA levels were found in other measured brain regions in the alcohol and control groups. Conclusion: Chronic alcohol exposure induced the region-specific expression of BDNF and proBDNF and their respective receptors in the brain. These results suggest that BDNF and proBDNF signaling pathways may play major roles in alcohol preference and addiction.
机译：背景：酗酒是全世界严重的健康问题，导致各种身心障碍。研究表明，脑衍生的神经营养因子（BDNF）在酒精成瘾中起重要作用。 BDNF前体（ProBDNF）通过中枢神经系统中的单独的受体和途径表现出与BDNF不同的动作。然而，ProBDNF和BDNF在酒精成瘾中的影响尚不完全已知。目的：目的是鉴定慢性酒精暴露后ProBDNF和BDNF的表达模式和效果。方法：研究共40只雄性成年小鼠。建立了鼠标精神运动敏感性（PS）模型，以探讨慢性酒精暴露后BDNF和ProBDNF治疗的影响。进行逆转录PCR（RT-PCR）以在慢性酒精曝光后慢性酒精暴露后的前额外皮层，海马和昆明小鼠的昆明小鼠的背纹素中测量BDNF，TRKB，P75NTR和Sortilin的mRNA水平。结果：在昆明小鼠，慢性酒精暴露上调的BDNF和TRKB mRNA水平在前额叶皮质，但在背体中减少了Sortilin和P75 mRNA水平。在醇和对照组的其他测量脑区中没有发现mRNA水平的变化。结论：慢性酒精暴露诱导脑中BDNF和ProBDNF的特异性表达及其各自受体。这些结果表明BDNF和ProBDNF信号传导途径可能在酒精偏好和成瘾中发挥主要作用。

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    Yang Jin-Wei; Ma Wei; Yang Yan-lei; Wang Xian-bin; Li Xing-tong; Wang Tong-tong; Wang Xiang-peng; Gao Wei; Li Jun-yan; Zhou Xin-fu; Guo Jian-hui; Li Li-yan;

  • 作者单位

    Kunming Med Univ Inst Neurosci 1168 Chunrong West Rd Kunming 650500 Yunnan Peoples R China;

    Kunming Med Univ Inst Neurosci 1168 Chunrong West Rd Kunming 650500 Yunnan Peoples R China;

    Kunming Med Univ Inst Neurosci 1168 Chunrong West Rd Kunming 650500 Yunnan Peoples R China;

    Kunming Med Univ Inst Neurosci 1168 Chunrong West Rd Kunming 650500 Yunnan Peoples R China;

    Kunming Med Univ Inst Neurosci 1168 Chunrong West Rd Kunming 650500 Yunnan Peoples R China;

    Kunming Med Univ Inst Neurosci 1168 Chunrong West Rd Kunming 650500 Yunnan Peoples R China;

    Kunming Med Univ Inst Neurosci 1168 Chunrong West Rd Kunming 650500 Yunnan Peoples R China;

    Kunming Med Univ Inst Neurosci 1168 Chunrong West Rd Kunming 650500 Yunnan Peoples R China;

    First Peoples Hosp Kunming City Dept Neurosurg Kunming Yunnan Peoples R China;

    Univ South Australia Fac Hlth Sci Sansom Inst Sch Pharm &

    Med Sci Adelaide SA 5001 Australia;

    First Peoples Hosp Yunnan Prov Dept Gen Surg 2 157 Jinbi Rd Kunming 650032 Yunnan Peoples R;

    Kunming Med Univ Inst Neurosci 1168 Chunrong West Rd Kunming 650500 Yunnan Peoples R China;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 药学;
  • 关键词

    BDNF; proBDNF; chronic alcohol exposure; alcohol preference;

    机译：BDNF;probdnf;慢性酒精曝光;酒精偏好;

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