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首页> 外文期刊>AIDS care. >Baseline predictors of three types of antiretroviral therapy (ART) adherence: A 2-year follow-up.
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Baseline predictors of three types of antiretroviral therapy (ART) adherence: A 2-year follow-up.

机译：三种抗逆转录病毒疗法（ART）依从性的基线预测指标：随访2年。

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The purposes of the study were to measure adherence with antiretroviral therapy to dose, schedule, and dietary instructions in a sample of patients with HIV infection in Stockholm, Sweden, over a 2-year period and identify baseline predictors of the three types of adherence. The study cohort consists of 144 patients who completed at least six out of seven follow-up self-reported adherence questionnaires. Baseline self-administrated questionnaire examined socio-demographics, medication-related, psychological, cognitive, and social context factors and self-reported adherence. Biomedical data were obtained through patients' medical records. Summary dose, schedule, and dietary instructions adherence scores provided outcome measures reflecting 100% adherence across all time points or not 100% adherence during at least one measurement period. A total of 61% maintained consistent full-dose adherence throughout baseline and all follow-up visits and equivalent proportion of 100% schedule adherence was 39%. Among patients with dietary instructions, 37% retained consistent adherence at all visits. Only schedule adherence was predicted by baseline data; perceived pressures from medical staff to take HIV medications (OR 0.51, p < .05), life stress (OR 0.13, p < .01), ART health concerns (OR 0.19, p < .01), and ART prolongs one's life (OR 0.39, p < .05) predicted reduced schedule adherence over time. Perceived medication pressures from those close to the patient (OR 1.76, p < .05), post-traumatic stress disorder symptoms (OR 1.07 p<.01), and adherence self-efficacy (OR 3.50, p < .05) predicted positive schedule adherence over time. These results clearly illustrate difficulties in sustaining ART adherent behaviour, in particular schedule and dietary restrictions, over time and thus emphasizes the importance of multiple periodic assessments of all three types of adherence. Interventions aimed at improving schedule adherence should in particular focus on psychological and cognitive factors.
机译：该研究的目的是在瑞典斯德哥尔摩为期2年的HIV感染患者样本中，测量抗逆转录病毒疗法对依从性的剂量，时间表和饮食指导的依从性，并确定三种依从性的基线预测指标。该研究队列由144位患者组成，这些患者至少完成了7份自我报告的依从性问卷调查中的6份。自我管理的基线问卷调查了社会人口统计学，与药物相关的，心理，认知和社会背景因素以及自我报告的依从性。生物医学数据是通过患者的病历获得的。总结剂量，时间表和饮食说明的依从性评分可提供结果指标，反映出所有时间点的依从性均为100％，或者至少在一个测量期间内并非100％依从性。共有61％的人在整个基线和所有后续随访期间保持一致的全剂量依从性，而100％的计划依从性的等效比例为39％。在接受饮食指导的患者中，37％的患者在每次就诊时均保持一致的依从性。基线数据仅预测了计划的遵守情况;感受到医务人员服用HIV药物的压力（OR 0.51，p <.05），生活压力（OR 0.13，p <.01），ART健康问题（OR 0.19，p <.01）和ART可以延长人的寿命（ OR 0.39，p <.05）预测随着时间的推移时间表依从性降低。接近患者的感知药物压力（OR 1.76，p <.05），创伤后应激障碍症状（OR 1.07 p <.01）和依从性自我效能感（OR 3.50，p <.05）预测为阳性随时间安排遵守情况。这些结果清楚地说明了随着时间的推移维持ART依从性行为的困难，特别是日程安排和饮食限制，因此强调了对所有三种依从性进行多次定期评估的重要性。旨在改善时间表依从性的干预措施应特别关注心理和认知因素。

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