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首页> 外文期刊>AIDS care. >Is single-dose NVP relevant in the era of more efficacious PMTCT regimens? Lessons from Zambia.
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Is single-dose NVP relevant in the era of more efficacious PMTCT regimens? Lessons from Zambia.

机译：在更有效的PMTCT方案时代，单剂量NVP是否有意义？赞比亚的教训。

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摘要

For almost a decade, single-dose nevirapine (sdNVP) has been proven to be a safe and effective drug for the prevention of mother-to-child transmission (PMTCT) of HIV. With the advent of the use of more efficacious combination therapy strategy in reducing mother-to-child transmission, sdNVP has been relegated as a lower tier intervention. Availability of infrastructural capacity coupled with the practical reality that very few women attend an antenatal clinic more than once makes universal implementation of combination therapy a challenge. This retrospective review examined PMTCT programmatic indicators following the introduction of sdNVP at first contact in selected sites. Data from 79 PMTCT sites was reviewed from April 2006 to March 2007 (when sdNVP was offered only after 32 weeks) and compared to the period of April 2007-March 2008. In the pre-intervention period (April 2006-March 2007), the monthly average of pregnant women who received sdNVP per site was 5.02. Post-intervention (April 2007-March 2008), the monthly average increased by 59% to 7.97 (p-value<0.05). In pre-intervention period when sdNVP was dispensed at 32 weeks, the average proportion of pregnant women who received antiretroviral prophylaxis was 59%. This increased to 82% after the intervention. Current systems for dispensing sdNVP may be used as a foundation for implementation of more efficacious PMTCT regimens. The sdNVP administered at first contact should be a safety net for women who are unable to receive more efficacious regimen.
机译：近十年来，单剂量奈韦拉平（sdNVP）已被证明是预防HIV母婴传播（PMTCT）的安全有效药物。随着使用更有效的联合治疗策略来减少母婴传播，sdNVP已被降级为较低级别的干预措施。基础设施的可用性以及实际情况是，很少有妇女会多次参加产前诊所，这使得联合治疗的普遍实施成为一个挑战。这项回顾性审查在选定场所首次接触sdNVP后引入了PMTCT计划指标。回顾了2006年4月至2007年3月（仅在32周后才提供sdNVP）的79个PMTCT站点的数据，并将其与2007年4月至2008年3月的时间进行了比较。在干预前的时间段（2006年4月至2007年3月），每个站点接受sdNVP的孕妇每月平均为5.02。干预后（2007年4月至2008年3月），每月平均数增加了59％，达到7.97（p值<0.05）。在干预前的第32周分发sdNVP期间，接受抗逆转录病毒预防的孕妇平均比例为59％。干预后增加到82％。用于分配sdNVP的当前系统可以用作实施更有效的PMTCT方案的基础。对于无法接受更有效治疗方案的女性，初次接触时使用sdNVP应该是一个安全网。

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