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首页> 外文期刊>AIDS care. >Comparison of colorectal cancer screening and diagnoses in HIV-positive and HIV-negative veterans
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Comparison of colorectal cancer screening and diagnoses in HIV-positive and HIV-negative veterans

机译：HIV阳性和HIV阴性退伍军人大肠癌筛查和诊断的比较

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Non-AIDS defining malignancies, including colorectal cancer (CRC), are emerging as significant problems in HIV-infected people. Some data suggest that HIV-positive patients have higher incidence of CRC at younger ages than those who are HIV-negative. This investigation examined CRC rates and screening types and trends between 943 HIV-infected cases and their age, race, and gender matched HIV-negative controls (n = 943) from 1 January 2005 to 31 December 2008 at the Atlanta VA Medical Center. The most common screening type among these patients was fecal occult blood testing (FOBT), but colonoscopies were more common in the controls (16.4% for cases, 27.5% for controls; p < 0.0001). Almost half of all patients included in this analysis did not have any screening for CRC during the four years of follow-up even though average age was 55 years. Fifty-one percent of cases had at least one screening test during follow-up compared to 48% of the controls; 7.6% of the cases had a screening each of the four years compared to only 2.4% of the controls (p < 0.0001). Ten HIV-positive patients were diagnosed with CRC during the study period compared to no CRC diagnoses among controls (p = 0.0015), though there was no difference in the diagnosis of colon polyps (4.6% vs. 5.1%, p = 0.5911). These data also suggest a discrepancy in CRC incidence between race and age groups: 80% of HIV-positive cases diagnosed with CRC during the study were black and two were less than 50 years of age. Future studies will need to address whether different recommendations are needed for screening based on HIV status, younger age, or race.
机译：非艾滋病毒定义的恶性肿瘤，包括结直肠癌（CRC），正成为艾滋病毒感染者的重大问题。一些数据表明，HIV阳性患者比HIV阴性患者年轻时CRC的发生率更高。该研究调查了2005年1月1日至2008年12月31日在亚特兰大VA医疗中心接受检查的943例HIV感染者及其年龄，种族和性别匹配的HIV阴性对照（n = 943）之间的CRC率，筛查类型和趋势。这些患者中最常见的筛查类型是粪便潜血测试（FOBT），但结肠镜检查在对照组中更为常见（病例为16.4％，对照组为27.5％; p <0.0001）。尽管平均年龄为55岁，但在随访的四年中，几乎没有一半的患者没有接受CRC筛查。随访期间有51％的病例至少进行了一次筛查测试，而对照组为48％。四年中每年进行筛查的病例为7.6％，而对照组仅为2.4％（p <0.0001）。在研究期间，有10例HIV阳性患者被诊断出CRC，而对照组之间没有CRC诊断（p = 0.0015），尽管结肠息肉的诊断没有差异（4.6％vs. 5.1％，p = 0.5911）。这些数据还表明，种族和年龄组之间的CRC发病率存在差异：在研究期间被诊断出CRC的HIV阳性病例中，有80％是黑人，其中两个年龄不到50岁。未来的研究将需要解决是否需要根据艾滋病毒状况，年龄或种族进行不同的筛查建议。

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