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首页> 外文期刊>AIDS care. >Preexposure prophylaxis (PrEP) of HIV infection in France: A nationwide cross-sectional study (PREVIC study)
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Preexposure prophylaxis (PrEP) of HIV infection in France: A nationwide cross-sectional study (PREVIC study)

机译：法国的HIV暴露前预防（PrEP）：一项全国性横断面研究（PREVIC研究）

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Although preliminary studies showed that preexposure prophylaxis (PrEP) lowers the HIV transmission in individuals with HIV, confirmative trials are ongoing and PrEP is not routinely recommended. The aim of this study was to assess whether individuals with HIV share antiretroviral (ARV) drugs for PrEP and to describe awareness and discussion on PrEP in this population. A cross-sectional survey was conducted in France in 23 representative departments of infectious diseases and internal medicine. Physicians administered an anonymous standardized questionnaire to all individuals with HIV receiving ARVs and followed between 24 and 31 October 2011. The questionnaire included items regarding PrEP (awareness; discussion with their close circle, physician or patients' association; experience), personal sociodemographic characteristics, risk behaviors and HIV status of the participants. Five hundred and ninety three participants were recruited: male 74.2% (men who have sex with men 52.4%, heterosexuals 21.6%), member of patient's association 9.8%. Half of them (50.6%) lived with a stable partner and 35.2% with an HIV-negative partner. Almost half (41.8%) were aware and 29.5% had had discussion about PrEP. In logistic regression, awareness and discussion on PrEP were more frequent: (1) among males, in patients' association members (p < 0.001 for both) and in nonheterosexuals (p =0.023 and 0.057, respectively); (2) among women, in those not living with a stable partner (p =0.035 and p =0.03, respectively) or living with an HIV-negative partner (p = 0.049 and p =0.083, respectively). One percent of the participants declared having shared ARVs with someone and 8.3% reported PrEP in their close circle. Men reporting PrEP in their close circle shared ARVs more frequently than those who did not (10.3% vs. 0.2%, p < 0.001). Today, individuals with HIV do not seem to widely share personal ARVs for PrEP with seronegative people. A significant number of individuals with HIV are aware of and commonly discuss PrEP.
机译：尽管初步研究表明，暴露前预防（PrEP）可以降低HIV感染者的HIV传播，但正在进行确证试验，不建议常规使用PrEP。这项研究的目的是评估艾滋病毒感染者是否为PrEP共享抗逆转录病毒（ARV）药物，并描述该人群对PrEP的认识和讨论。在法国的23个代表传染病和内科的部门进行了横断面调查。医师向所有接受ARV的HIV感染者进行了匿名的标准化问卷调查，随后于2011年10月24日至31日进行了调查。该问卷包括有关PrEP（意识;与他们的密友圈，医师或患者协会的讨论;经验），个人社会人口统计学特征，参与者的危险行为和艾滋病毒状况。招募了593名参与者：男性74.2％（与男性发生性关系的男人52.4％，异性恋者21.6％），患者协会成员9.8％。其中一半（50.6％）与稳定伴侣住在一起，35.2％与HIV阴性伴侣住在一起。几乎一半（41.8％）知道并且29.5％的人们讨论过PrEP。在逻辑回归中，对PrEP的认识和讨论更为频繁：（1）在男性，患者协会成员中（两者均p <0.001）和在非异性恋者中（分别为p = 0.023和0.057）; （2）在妇女中，那些没有与稳定伴侣生活的妇女（分别为p = 0.035和p = 0.03）或与HIV阴性伴侣生活的妇女（分别为p = 0.049和p = 0.083）。百分之一的参与者宣布与某人共享ARV，而8.3％的参与者则在其接近的圈子中报告了PrEP。在其近距离内报告PrEP的男性比那些没有报告PrEP的男性更常见（10.3％vs. 0.2％，p <0.001）。如今，HIV感染者似乎并未与血清反应阴性的人广泛共享PrEP的个人ARV。许多艾滋病毒感染者了解并通常讨论PrEP。

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