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首页> 外文期刊>AIDS care. >Coronary artery disease risk reduction in HIV-infected persons: a comparative analysis
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Coronary artery disease risk reduction in HIV-infected persons: a comparative analysis

机译：减少艾滋病毒感染者的冠状动脉疾病风险：比较分析

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Despite an increased risk of coronary artery disease (CAD) in persons infected with human immunodeficiency virus (HIV), few data are available on primary prevention of CAD in this population. In this retrospective cohort study, HIV-infected patients treated in an academic medical center HIV Specialty Clinic between 1996 and 2010 were matched by age, gender, and ethnicity to a cohort of presumed uninfected persons followed in an academic medical center Internal Medicine primary care clinic. We compared CAD primary prevention care practices between the two clinics, including use of aspirin, HMG-CoA reductase inhibitors ("statins"), and anti-hypertensive drugs. CAD risk between the two groups was assessed with 10-year Framingham CAD risk scores. In the comparative analysis, 890 HIV-infected persons were compared to 807 controls. Ten-year Framingham CAD Risk Scores were similar in the two groups (median, 3; interquartile range [IQR], 0-5). After adjusting for relevant risk factors, HIV-infected persons were less likely to be prescribed aspirin (odds ratio [OR] 0.53; 95% confidence interval [CI], 0.40-0.71), statins (OR, 0.70; 95% CI, 0.53-0.92), and anti-hypertensive drugs (OR, 0.63; 95% CI, 0.50-0.79) than persons in the control group. In summary, when compared to demographically similar uninfected persons, HIV-infected persons treated in an HIV specialty clinic were less likely to be prescribed medications appropriate for CAD risk reduction. Improving primary preventative CAD care in HIV specialty clinic populations is an important step toward diminishing risk of heart disease in HIV-infected persons.
机译：尽管感染了人类免疫缺陷病毒（HIV）的人患冠状动脉疾病（CAD）的风险增加，但在该人群中，关于CAD的一级预防的数据很少。在这项回顾性队列研究中，将1996年至2010年在学术医学中心HIV专科诊所治疗的HIV感染患者的年龄，性别和种族与一组未感染者进行了匹配，随后在学术医学中心内科初级保健诊所随访。我们比较了两个诊所之间的CAD一级预防保健实践，包括使用阿司匹林，HMG-CoA还原酶抑制剂（“他汀”）和抗高血压药。两组之间的CAD风险通过10年Framingham CAD风险评分进行评估。在比较分析中，将890名HIV感染者与807名对照进行了比较。两组的十年弗雷明汉CAD风险评分相似（中位数为3;四分位间距[IQR]为0-5）。在调整了相关的危险因素后，艾滋病毒感染者不太可能开具阿司匹林（赔率[OR]为0.53; 95％置信区间[CI]为0.40-0.71），他汀类药物（OR为0.70; 95％CI为0.53） -0.92）和抗高血压药物（OR，0.63; 95％CI，0.50-0.79）高于对照组。总之，与人口统计学上未感染的人相比，在HIV专科门诊接受治疗的HIV感染者不太可能开出适合降低CAD风险的处方药。改善艾滋病专科门诊人群的初级预防性CAD护理，是降低艾滋病毒感染者心脏病风险的重要一步。

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