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首页> 外文期刊>AIDS Research and Human Retroviruses >Enrollment, retention, and visit attendance in the University of North Carolina Center for AIDS Research HIV clinical cohort, 2001-2007.
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Enrollment, retention, and visit attendance in the University of North Carolina Center for AIDS Research HIV clinical cohort, 2001-2007.

机译：北卡罗来纳大学艾滋病研究中心的入组，保留和出诊，2001-2007年。

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Predictors of study retention and scheduled visit attendance in the University of North Carolina Center for AIDS Research (UNC CFAR) prospective clinical cohort of HIV-infected patients enrolled between 1 January 2001 and 1 January 2008 are reported. At study entry, 1636 participants were 32% female, 58% were African-American, 49% had not received HIV care elsewhere, 71% were receiving or initiated combination antiretroviral therapy, and 26% were diagnosed with AIDS, with median (quartiles) age of 40 (34; 47) years, distance to clinic of 45 (21; 70) miles, HIV-1 RNA of 1396 (200; 26,750) copies/ml, and CD4 of 374 (182; 602) cells/mm(3). Participants contributed a median of 7 (4; 13) scheduled visits and 2.25 (1.0; 3.9) years alive under follow-up. During 6134 person-years of follow-up, 414 participants dropped out and 145 died. Accounting for differences in death by participant characteristics, the 6-year cumulative probability of retention was 67% [95% confidence limits (CL): 65, 70%], with 6.75 (95% CL: 6.13, 7.43) drop outs per 100 person-years. In a multivariable Cox proportional hazards model, retention was higher among participants who were insured, had not received HIV care elsewhere, had controlled HIV viremia, and were living in nonurban areas or proximate to the clinic. In a multivariable modified Poisson regression model that accounted for differences in drop out and death by participant characteristics, visit attendance was higher among older, AIDS-diagnosed, immune compromised, and cART-initiated participants. The UNC CFAR clinical cohort has ample enrollment with retention and visit attendance modestly influenced by factors such as disease severity.
机译：据报道，在2001年1月1日至2008年1月之间招募的北卡罗来纳大学艾滋病研究中心（UNC CFAR）的前瞻性临床队列中的HIV感染患者的研究保留率和预定的就诊预测指标。在研究开始时，有1636名参与者是32％的女性，58％的非裔美国人，49％的人未在其他地方接受过HIV治疗，71％的人正在接受或开始联合抗逆转录病毒疗法，以及26％的患者被诊断出患有AIDS，中位数年龄40（34; 47）岁，距诊所45（21; 70）英里，HIV-1 RNA 1396（200; 26,750）拷贝/毫升，CD4 374（182; 602）细胞/毫米（ 3）。在随访中，参与者贡献了7（4; 13）次定期访问的中位生命和2.25（1.0; 3.9）年的活期。在6134人年的随访中，有414人退出了研究，有145人死亡。考虑到参加者特征造成的死亡差异，6年累积保留率是67％[95％置信度（CL）：65，70％]，每100人中有6.75（95％CL：6.13，7.43）辍学人年。在多变量Cox比例风险模型中，参保者，未在其他地方接受过HIV治疗，已控制HIV病毒血症且居住在非城市地区或靠近诊所的参与者中的保留率更高。在多变量修正的Poisson回归模型中，参与者的辍学和死亡差异是不同的，在年长，经AIDS诊断，免疫受损和cART发起的参与者中，就诊率更高。 UNC CFAR临床队列的入组人数很多，受疾病严重程度等因素的影响较小。

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