Short communication: Neutralizing antibodies in HIV-1-infected Brazilian individuals

AlmeidaD.V.; MorgadoM.G.; C么rtesF.H.; Guimar茫esM.L.; Mendon莽a-LimaL.; PilottoJ.H.; GrinsztejnB.; VelosoV.G.; BongertzV.

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Short communication: Neutralizing antibodies in HIV-1-infected Brazilian individuals

机译：简短交流：中和HIV-1感染的巴西个体的抗体

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Tests for the detection of the humoral immune response to HIV-1 have to be standardized and established, demanding regional efforts. For this purpose the neutralizing antibody (NAb) assay for HIV-1 in TZM-bl cells was introduced in Brazil. Twenty plasma samples from HIV-1-infected individuals were assayed: 10 progressors and 10 long-term nonprogressors. These were tested against eight env-pseudotyped viruses (psVs) in the TZM-bl NAb assay and against HIV-1 strain HTLV/IIIB (HIV-1 IIIB) in primary lymphocytes. Forty-four percent of the samples showed neutralizing titers for psVs and 55% for HIV-1 IIIB. Plasma from progressors showed a broader neutralization and a higher potency. The introduction of these reference reagents encourages the participation of Brazil in future comparative assessments of anti-HIV-1 antibodies.

机译：必须对检测对HIV-1的体液免疫反应的检测进行标准化和建立，这需要区域努力。为此目的，在巴西引入了TZM-b1细胞中HIV-1的中和抗体（NAb）分析。分析了来自HIV-1感染者的20个血浆样品：10个进展者和10个长期非进展者。在TZM-bl NAb分析中针对八种env假型病毒（psVs）对它们进行了测试，对原代淋巴细胞中的HIV-1株HTLV / IIIB（HIV-1 IIIB）进行了测试。百分之四十四的样本对psV病毒显示中和效价，对HIV-1 IIIB的病毒显示55％的效价。进展者的血浆显示出更广泛的中和作用和更高的效力。这些参考试剂的引入鼓励巴西参与抗HIV-1抗体的未来比较评估。

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《AIDS Research and Human Retroviruses》 |2013年第3期|共5页
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AlmeidaD.V.; MorgadoM.G.; C么rtesF.H.; Guimar茫esM.L.; Mendon莽a-LimaL.; PilottoJ.H.; GrinsztejnB.; VelosoV.G.; BongertzV.;
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正文语种 eng
中图分类传染病;
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1. Short communication: Neutralizing antibodies in HIV-1-infected Brazilian individuals [J] . AlmeidaD.V., MorgadoM.G., C么rtesF.H., AIDS Research and Human Retroviruses . 2013,第3期

机译：简短交流：中和HIV-1感染的巴西个体的抗体
2. Longitudinal Analysis Reveals Early Development of Three MPER-Directed Neutralizing Antibody Lineages from an HIV-1-Infected Individual [J] . Krebs Shelly J., Kwon Young D., Schramm Chaim A., Immunity . 2019,第3期

机译：纵向分析揭示了来自HIV-1感染个体的三种MPER导向的中和抗体谱系的早期发展
3. Broadly Neutralizing Antibody Responses in a Subset of HIV-1-Infected Individuals in Chennai, India [J] . Syed Iqbal Hussain, Nandagopal Panneerselvam, Suniti Solomon, Journal of the International Association of Providers of AIDS Care. . 2017,第2期

机译：在印度钦奈，一组HIV-1感染者的亚群广泛中和抗体反应。
4. Reconstitution and Characterization of Antibody Repertoires of HIV-1-Infected "Elite Neutralizes" by IgG Cell Surface Display [C] . Mei-Yun Zhang, Zehua Sun, Jingjing Li, PEGS . 2015

机译：通过IgG细胞表面显示器重构和表征HIV-1感染的“精英中和”的抗体曲目
5. Two Sides to the Same Antibody: Assessing the Role of Neutralizing and Non-neutralizing Antibodies in Mother-to-child Transmission of HIV-1 [D] . Ghulam-Smith, Melissa 2021

机译：两侧到同一抗体：评估中和和非中和抗体在HIV-1的母儿传播中的作用
6. Short Communication: Neutralizing Antibodies in HIV-1-Infected Brazilian Individuals [O] . Dalziza Victalina Almeida, Mariza Gonçalvez Morgado, Fernanda Heloise Côrtes, -1

机译：简短交流：中和HIV-1感染的巴西个体的抗体
7. Neutralizing Antibody Response and Antibody-Dependent Cellular Cytotoxicity in HIV-1-Infected Individuals from Guinea-Bissau and Denmark [O] . Borggren, Marie, Jensen, Sanne Skov, Heyndrickx, Leo, 2016

机译：来自几内亚比绍和丹麦的HIV-1感染个体的中和抗体反应和抗体依赖性细胞毒性

Short communication: Neutralizing antibodies in HIV-1-infected Brazilian individuals

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