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首页> 外文期刊>AIDS Research and Human Retroviruses >Short communication: Broader t cell responses directed against human immunodeficiency virus type 1 in infected chinese individuals through blood-borne transmission in comparison with mucosal transmission
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Short communication: Broader t cell responses directed against human immunodeficiency virus type 1 in infected chinese individuals through blood-borne transmission in comparison with mucosal transmission

机译：简短交流：与中国人相比，中国人通过血源传播与黏膜传播相比，针对人类免疫缺陷病毒1型的t细胞反应更为广泛

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摘要

Cellular immune responses play a critical role in the control of human immunodeficiency virus type 1 (HIV-1), but less is known about the impact of transmission routes on immune defenses against HIV-1. Here, we report that subjects infected with HIV-1 through contaminated blood showed stronger HIV-specific T cell responses than those infected through mucosa, both in breadth (6.9±2.5 vs. 2.3±0.5, p=0.0293) and in magnitude [1270.0±544.9 vs. 409.5±121.3 SFU per million peripheral blood mononuclear cells (PBMCs), p=0.0223], by using a matrix of 404 overlapping peptides spanning all expressed HIV-1 proteins in an interferon (IFN)-γ enzyme-linked immunospot (ELISpot) assay. Our observation indicates that different mechanisms might be involved in the priming/generating of anti-HIV-specific T cell responses through different transmission routes.
机译：细胞免疫应答在控制人类1型免疫缺陷病毒（HIV-1）中起着关键作用，但关于传播途径对HIV-1免疫防御的影响知之甚少。在这里，我们报道了通过污染血液感染HIV-1的受试者在宽度（6.9±2.5 vs. 2.3±0.5，p = 0.0293）和幅度[1270.0]方面均比通过粘膜感染的受试者表现出更强的HIV特异性T细胞反应。通过使用干扰素（IFN）-γ酶联免疫斑点中跨越所有表达的HIV-1蛋白的404个重叠肽矩阵，将每百万个外周血单核细胞（PBMC）的±544.9 vs. 409.5±121.3 SFU，p = 0.0223] （ELISpot）分析。我们的观察表明，通过不同的传播途径引发/产生抗HIV特异性T细胞应答可能涉及不同的机制。

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