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首页> 外文期刊>The Pediatric infectious disease journal >Clinical Analysis of 25 COVID-19 Infections in Children
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Clinical Analysis of 25 COVID-19 Infections in Children

机译：25家Covid-19儿童感染的临床分析

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Background: To describe the characteristics of clinical manifestations of children with 2019 novel coronavirus (2019-nCoV) infection in Chongqing. Methods: All 25 children with laboratory-confirmed 2019-nCoV infection by real-time reverse transcription-PCR (RNA-PCR) were admitted from the 4 designated treatment hospitals of 2019-nCoV in Chongqing from January 19 to March 12, 2020. Clinical data and epidemiologic history of these patients were retrospectively collected and analyzed. Results: The diagnosis was confirmed through RNA-PCR testing. Among the 25 cases, 14 were males and 11 were females. The median age was 11.0 (6.3-14.5) years (range 0.6-17.0 years). All children were related to a family cluster outbreak, and 7 children (28%) with a travel or residence history in Hubei Province. These patients could be categorized into different clinical types, including 8 (32%) asymptomatic, 4 (16%) very mild cases and 13 (52%) common cases. No severe or critical cases were identified. The most common symptoms were cough (13 cases, 52%) and fever (6 cases, 24%). The duration time of clinical symptoms was 13.0 (8.0-25.0) days. In the 25 cases, on admission, 21 cases (84%) had normal white blood cell counts, while only 2 cases (8%) more than 10 x 10(9)/L and 2 cases (8%) less than 4 x 10(9)/L, respectively; 22 cases(88%) had normal CD4+ T lymphocyte counts, while in the remaining 3 cases(8%) this increased mildly; 23 cases had normal CD8+ T lymphocyte counts, while in the remaining 2 cases (8%) CD8+ T lymphocyte counts were mildly increased as well. All Lymphocyte counts were normal. There were no statistical differences of lab results between the groups of asymptomatic cases, mild cases and common cases. There were only 13 cases with abnormal CT imaging, most of which were located in the subpleural area of the bottom of the lung. All patients were treated with interferon, 6 cases combined with Ribavirin, and 12 cases combined with lopinavir or ritonavir. The days from onset to RNA turning negative was 15.20 +/- 6.54 days. There was no significant difference of RNA turning negative between the groups of interferon, interferon plus ribavirin and interferon plus lopinavir or ritonavir treatment. All the cases recovered and were discharged from hospital. Conclusions: The morbidity of 2019-nCoV infection in children is lower than in adults and the clinical manifestations and inflammatory biomarkers in children are nonspecific and milder than that in adults. RNA-PCR test is still the most reliable diagnostic method, especially for asymptomatic patients.
机译：背景：描述重庆患儿童临床表现的特征方法：从2020年1月19日至3月12日至3月12日，重庆的4名指定治疗医院，临床这些患者的数据和流行病学史回顾性收集和分析。结果：通过RNA-PCR测试证实了诊断。在25例中，14例为男性，11例是女性。中位数年龄为11.0（6.3-14.5）年（范围为0.6-17.0岁）。所有儿童与湖北省旅行或居留历史有关的家庭集群爆发和7名儿童（28％）。这些患者可以分为不同的临床类型，包括8（32％）无症状，4（16％）非常轻微的病例，13例（52％）常见的病例。没有确定严重或严重的病例。最常见的症状咳嗽（13例，52％）和发烧（6例，24％）。临床症状的持续时间为13.0（8.0-25.0）天。在25例之前，入院时，21例（84％）有正常的白细胞计数，而只有2例（8％）超过10×10（9）/ L和2例（8％）小于4 x分别为10（9）/ L; 22例（88％）具有正常的CD4 + T淋巴细胞计数，而在剩余的3例（8％）中，这种温和的增加; 23例具有正常的CD8 + T淋巴细胞计数，而在其余2例中（8％）CD8 + T淋巴细胞计数也温和地增加。所有淋巴细胞计数都正常。无症状病例组之间的实验室结果没有统计学差异，轻度病例和常见情况。 CT成像只有13例，其中大部分位于肺部底部的副区。所有患者均用干扰素治疗，6例与利巴韦林合并，12例与Lopinavir或Ritonavir合并。从发病到RNA转向负数的日子为15.20 +/- 6.54天。在干扰素，干扰素加上利巴韦林和干扰素加上洛诺瓦韦或ritonavir治疗中没有显着差异。所有案件恢复并从医院排放。结论：2019年儿童感染的发病率低于成人，儿童临床表现和炎症生物标志物比成年人在内。 RNA-PCR试验仍是最可靠的诊断方法，特别是对于无症状患者。

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