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首页> 外文期刊>Biotechnology Progress >Selection of microbial mutants tolerant to extreme environmental stressusing continuous culture-control design
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Selection of microbial mutants tolerant to extreme environmental stressusing continuous culture-control design

机译：使用连续培养控制设计选择耐极端环境胁迫的微生物突变体

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摘要

The design of controllers for a continuous selection technique (BOICS; Brown and Oliver, 1982) is considered. This technique is used to obtain microbial mutants that are tolerant to extreme environmental stress. Applications of BOICS have been hampered by the problem of controller design. In this paper, a modified implementation of BOICS is considered which has a number of practical advantages. A model-based approach to controller design is taken. The case in which the stress is due to an inhibitory substance in the growth environment is considered. The analysis is intended to be applicable to any reasonable combination of organism and inhibitor. Conventional linear and time-invariant controllers are considered. Guidelines for the selection of controller parameters' values are suggested. The application of these guidelines requires that certain process parameters' values be identified. Methods by which these parameters' values can be identified are suggested. Simulation results indicate that the resulting controllers perform satisfactorily. This is confirmed by experimental data from a model selection experiment. A recipe for the design of controllers is a necessary part of a protocol for BOICS. It is hoped that the solution to the controller design problem that is offered in this paper will encourage further applications for the technique.
机译：考虑了用于连续选择技术的控制器的设计（BOICS; Brown和Oliver，1982）。该技术用于获得耐极端环境胁迫的微生物突变体。控制器设计的问题阻碍了BOICS的应用。本文考虑了BOICS的改进实现，它具有许多实际优势。采用了基于模型的控制器设计方法。考虑应力是由于生长环境中的抑制物质引起的情况。该分析旨在适用于生物体和抑制剂的任何合理组合。考虑传统的线性和时不变控制器。建议选择控制器参数值的准则。这些准则的应用要求确定某些过程参数的值。建议了识别这些参数值的方法。仿真结果表明，所得控制器的性能令人满意。来自模型选择实验的实验数据证实了这一点。控制器设计的诀窍是BOICS协议的必要部分。希望本文提供的控制器设计问题的解决方案将鼓励该技术的进一步应用。

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