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首页> 外文期刊>AIDS care. >Antiretroviral medication adherence among the REACH HIV-infected adolescent cohort in the USA.
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Antiretroviral medication adherence among the REACH HIV-infected adolescent cohort in the USA.

机译：在美国，REACH HIV感染的青少年队列中的抗逆转录病毒药物依从性。

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摘要

Adherence to highly active antiretroviral therapy (HAART) was investigated among HIV-infected adolescents recruited from 13 US cities into the REACH (Reaching for Excellence in Adolescent Care and Health) project, the first large-scale disease progression study of HIV-positive adolescents infected through sexual behaviour or injection drug use. Of 161 subjects, 7% could not correctly identify all their prescribed medications; 11% could identify them but reported never taking at least one medication. The majority (83%) reported taking all of their medications at least some of the time, but only 50% of these subjects reported full adherence. Therefore, only 41% of the sample reported full adherence. A strong association was found between adherence and reduced viral load. A CD4 level of > or = 500 cells/mm3 was also associated with adherence. Higher levels of depression were significantly associated with decreased adherence, and a trend was found for an association between number of medications prescribed and adherence. Strict adherence to HAART is critical for sustained suppression of viral replication allowing for immune recovery and reducing the risk of the selection of antiviral resistance. Adherence appears to be a serious problem among HIV-positive adolescents. Better education, intervention to relieve depression, and efforts to improve ease of medication use are essential.
机译：在美国13个城市招募的HIV感染青少年中，研究了对高活性抗逆转录病毒疗法（HAART）的依从性，该研究是REACH（卓越青少年保健和健康教育）项目中的一项，这是第一个大规模的HIV阳性青少年感染疾病进展研究通过性行为或注射毒品使用。在161名受试者中，有7％无法正确识别其所有处方药; 11％的人可以识别出他们的身材，但报告从未服用过至少一种药物。大多数（83％）报告至少在某些时间服用了所有药物，但只有50％的受试者报告完全服从。因此，只有41％的样本报告完全遵守。发现依从性和减少的病毒载量之间有很强的联系。 ≥500细胞/ mm3的CD4水平也与粘附有关。较高的抑郁水平与依从性下降显着相关，并且发现处方药的数量与依从性之间存在关联的趋势。严格遵守HAART对于持续抑制病毒复制，实现免疫恢复并降低选择抗病毒耐药性的风险至关重要。在艾滋病毒阳性的青少年中，依从性似乎是一个严重的问题。更好的教育，减轻抑郁的干预措施以及改善药物使用便利性的努力至关重要。

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