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首页> 外文期刊>AIDS care. >Reasons for non-adherence to antiretroviral therapy: patients' perspectives provide evidence of multiple causes.
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Reasons for non-adherence to antiretroviral therapy: patients' perspectives provide evidence of multiple causes.

机译：不坚持抗逆转录病毒疗法的原因：患者的观点提供了多种原因的证据。

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摘要

The objective of the study was to define common reasons for non-adherence (NA) to highly active antiretroviral therapy (HAART) and the number of reasons reported by non-adherent individuals. A confidential questionnaire was administered to HIV-seropositive patients taking proteinase inhibitor based HAART. Median self-reported adherence was 95% (n = 178, range = 60-100%). The most frequent reasons for at least 'sometimes' missing a dose were eating a meal at the wrong time (38.2%), oversleeping (36.3%), forgetting (35.0%) and being in a social situation (30.5%). The mean number of reasons occurring at least 'sometimes' was 3.2; 20% of patients gave six or more reasons; those reporting the lowest adherence reported a significantly greater numbers of reasons (rho = - 0.59; p < 0.001). Three factors were derived from the data by principal component analysis reflecting 'negative experiences of HAART', 'having a low priority for taking medication' and 'unintentionally missing doses', accounting for 53.8% of the variance. On multivariate analysis only the latter two factors were significantly related to NA (odds ratios 0.845 and 0.849, respectively). There was a wide spectrum of reasons for NA in our population. The number of reasons in an individual increased as adherence became less. A variety of modalities individualized for each patient are required to support patients with the lowest adherence.
机译：该研究的目的是确定对高活性抗逆转录病毒疗法（HAART）不依从（NA）的常见原因，以及不依从的个体报告的原因数量。对服用基于蛋白酶抑制剂的HAART的HIV阳性患者进行了保密问卷调查。自我报告的依从性中位数为95％（n = 178，范围= 60-100％）。至少“有时”缺少剂量的最常见原因是在错误的时间进餐（38.2％），睡过头（36.3％），忘记（35.0％）以及处于社交场合（30.5％）。至少“有时”发生的平均原因数量为3.2; 20％的患者给出了六个或更多原因;那些报告最低依从性的人报告了更多的原因（rho =-0.59; p <0.001）。通过主成分分析从数据中得出三个因素，反映出“ HAART的不良经历”，“服用药物的优先级较低”和“意外丢失剂量”，占方差的53.8％。在多变量分析中，仅后两个因素与NA显着相关（比值分别为0.845和0.849）。在我们的人群中，NA的原因广泛。个体的原因数量随着依从性的降低而增加。为了支持依从性最低的患者，需要为每位患者量身定制的多种方式。

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