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Alcohol-antiretroviral therapy interactive toxicity beliefs and daily medication adherence and alcohol use among people living with HIV

机译：艾滋病毒感染者中的抗酒精，抗逆转录病毒疗法互动毒性信念，日常用药依从性和饮酒

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Alcohol-antiretroviral therapy (ART) interactive toxicity beliefs reflect perceived adverse outcomes of mixing alcohol and ART. Previous research has shown a significant relationship between alcohol-ART interactive toxicity beliefs and ART non-adherence, over and above other correlates of non-adherence such as human immunodeficiency virus (HIV)symptoms and frequency of alcohol use. Most past studies have collected data over extended periods and have not determined if alcohol use and missed medications occur at the day-level among people holding interactive toxicity beliefs. Previous daily analyses, however, have been limited by self-reported adherence and relatively short periods of observation. To address these gaps in the literature, men and women living with HIV in Atlanta, GA, were enrolled in a 45-day observational cohort study. Daily alcohol use was collected using two-way interactive text message surveys and daily adherence was collected via the Wisepill device. Fifty-seven participants completed a measure of alcohol-ART interactive toxicity beliefs and contributed 2565 days of daily data. Participants who endorsed high levels of interactive toxicity beliefs had significantly more days when they missed doses of medication. Alcohol-antiretroviral toxicity beliefs predicted missing doses of medication on days when participants were drinking and on days when they were not drinking. Multilevel multivariate regressions showed that these toxicity beliefs predicted daily missed doses of medication over and above quantity of alcohol consumed, depression and general medication concerns. This study replicates and extends previous literature and indicates the necessity of addressing alcohol-ART toxicity beliefs within adherence interventions.
机译：酒精-抗逆转录病毒疗法（ART）的交互毒性信念反映了将酒精和ART混合使用的不良后果。先前的研究表明，除人类免疫缺陷病毒（HIV）症状和酒精使用频率等其他非黏附相关因素外，酒精-ART交互毒性信念与非黏附之间存在显着关系。过去的大多数研究都收集了较长时间的数据，还没有确定在具有互动毒性信念的人群中，是否每天都在酗酒和漏药。但是，以前的日常分析受到自我报告的依从性和相对较短的观察期的限制。为了弥补文献中的这些空白，乔治亚州亚特兰大市的艾滋病毒感染者男女参加了一项为期45天的观察性队列研究。通过双向互动文本消息调查收集每日饮酒量，并通过Wisepill设备收集每日依从性。 57名参与者完成了酒精-ART交互毒性信念的评估，并贡献了2565天的每日数据。赞同高水平交互毒性信念的参与者在错过服药剂量时有更多的日子。酒精抗逆转录病毒毒性信念预测参与者喝酒的日子和不喝酒的日子会丢失药物。多级多元回归分析显示，这些毒性信念预测了每天的药物误服量，饮酒量，抑郁症和一般用药问题除外。这项研究重复并扩展了先前的文献，并指出了在依从性干预措施中解决酒精-ART毒性信念的必要性。

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