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首页> 外文期刊>Biotechnology Progress >Clavulanic acid degradation in streptomyces clavuligerus fed-batch cultivations
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Clavulanic acid degradation in streptomyces clavuligerus fed-batch cultivations

机译：棒状链霉菌补料分批培养中棒酸的降解

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摘要

Clavulanic acid (CA) is an important antibiotic tat is produced by Streptomyces clavuligerus.CA is unstable and product degradation has turned out to have a major impact on product titers infed-batchcultivations.Thre diffeent types of experiments have been used to elucidate CA degradation under fed-batchcultivation conditions.First,the influence of individual medium compounds was examined.Second,degradation was monitored during the exponential growthphase in batch cultivations.Third,CA degradation was studied in the supernatant of samples taken during a fed-batch.In addition,dat afrom six fed-batch cultivations were studied toderive information about CA degradation during the production phase.These cultivations were based on a mineral medium,containing glycerol,glutamate,ammonium,and phosphate as the main nutrients.The amonium concentrationahd a large influence on the degradation rate constant.In addition,either changes in the subsrate availability or high concentratiohs of ammonium or glycerol cause a major increase in the degradationrate constant.Finally,a linear and a fuzzy logic model were made to predict CA degradation rates in these fed-batches.
机译：棒酸（CA）是棒状链霉菌（Streptomyces clavuligerus）产生的重要抗生素，CA不稳定且产品降解已对分批培养的产品效价产生重大影响。已经使用了不同的实验类型来阐明补料分批培养的条件。首先，考察了单个培养基化合物的影响。其次，在分批培养的指数生长期监测降解情况。第三，研究了分批补料的上清液中CA的降解情况。研究了六种补料分批培养的数据，以了解有关生产过程中CA降解的推论信息。这些培养以矿物培养基为基础，该培养基以甘油，谷氨酸，铵和磷酸盐为主要营养素。降解率常数。此外，底物利用率的变化或铵的高浓度或最后，建立了线性和模糊逻辑模型来预测这些补料批次中的CA降解速率。

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