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首页> 外文期刊>The Veterinary Clinics of North America. Food Animal Practice >Host Tolerance to Infection with the Bacteria that Cause Bovine Respiratory Disease
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Host Tolerance to Infection with the Bacteria that Cause Bovine Respiratory Disease

机译：宿主耐受感染导致牛呼吸道疾病的细菌

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摘要

Calves vary considerably in their pathologic and clinical responses to infection of the lung with bacteria. The reasons may include resistance to infection because of pre-existing immunity, development of effective immune responses, or infection with a minimally virulent bacterial strain. However, studies of natural disease and of experimental infections indicate that some calves develop only mild lung lesions and minimal clinical signs despite substantial numbers of pathogenic bacteria in the lung. This may represent "tolerance" to pulmonary infection because these calves are able to control their inflammatory responses or protect the lung from damage, without necessarily eliminating bacterial infection. Conversely, risk factors might predispose to bovine respiratory disease by triggering a loss of tolerance that results in a harmful inflammatory and tissue-damaging response to infection.
机译：犊牛在他们的病理学和临床反应中随着细菌感染肺的临床反应而变化很大。 原因可能包括由于预先存在的免疫，有效的免疫应答或具有最小毒性的细菌菌株的感染而导致感染的抗性。 然而，虽然肺部的大量致病细菌，但是，尽管肺中的致病细菌大量，一些小腿的研究表明，一些小腿仅开发轻度肺病变和最小的临床症状。 这可能代表肺部感染的“耐受性”，因为这些小腿能够控制其炎症反应或保护肺免受损伤，而不必消除细菌感染。 相反，危险因素可能通过引发耐受性丧失导致对感染有害的炎症和组织损害反应而导致耐受性的血管呼吸系统疾病。

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