...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>AIDS Research and Human Retroviruses >Short communication: Evaluation of GB virus C/hepatitis G viral load among HIV type 1-coinfected patients in S?o Paulo, Brazil
【24h】

Short communication: Evaluation of GB virus C/hepatitis G viral load among HIV type 1-coinfected patients in S?o Paulo, Brazil

机译：简短交流：在巴西圣保罗，对HIV 1型合并感染患者进行GB丙型肝炎病毒/ G型肝炎病毒载量评估

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Recent studies suggest that GB virus C/hepatitis G virus (GBV-C/HGV) infection in HIV-positive individuals is associated with a slower progression to AIDS, leading to a lower HIV viral load and higher counts of CD4 + T cells, although many studies have failed to demonstrate these beneficial effects. We developed a Real-Time PCR (TaqMan RT qPCR) to quantify the viral load of GBV-C/HGV in 102 HIV-1-infected patients, who were also evaluated for the presence of anti-E2. The prevalence of GBV-C/HGV infection was 21% among infected patients and the mean plasma viral load was 3.62±0.64 log 10 copies/ml. Despite the high prevalence, there was no statistical difference when we compared the mean viral load (p≤0.46) and the average count of CD4 + (p≤0.29) and CD8 + (p≤0.64) among patients infected by GBV-C/HGV and HIV and patients infected only by HIV. This fact can be explained by the number of patients included in the study. Nevertheless, compared to other studies, we observed a discrete number of patients with undetectable HIV load and lower median viral load in the group presenting GBV-C/HGV RNA. Our study suggests that there may be an impact on HIV viral load in GBV-C/HGV-coinfected patients. However, further studies are needed to elucidate the molecular and cellular mechanisms involved in this viral interaction, previously reported in other studies, with the aim of contributing to the development of new targets for drugs against HIV.
机译：最近的研究表明，在HIV阳性个体中，GB丙型肝炎病毒/ G型肝炎病毒（GBV-C / HGV）感染与艾滋病的进展较慢有关，导致HIV病毒载量降低和CD4 + T细胞计数升高，尽管许多研究未能证明这些有益作用。我们开发了实时荧光定量PCR（TaqMan RT qPCR）来量化102位HIV-1感染患者的GBV-C / HGV病毒载量，这些患者还评估了抗E2的存在。在感染的患者中，GBV-C / HGV感染的患病率为21％，平均血浆病毒载量为3.62±0.64 log 10个拷贝/ ml。尽管患病率很高，但是当我们比较受GBV-C /感染的患者的平均病毒载量（p≤0.46）和CD4 +（p≤0.29）和CD8 +（p≤0.64）的平均计数时，没有统计学差异。 HGV和HIV以及仅感染HIV的患者。这个事实可以通过研究中包括的患者数量来解释。然而，与其他研究相比，我们观察到在呈现GBV-C / HGV RNA的人群中有离散的HIV载量和中位病毒载量较低的患者。我们的研究表明，GBV-C / HGV合并感染的患者可能会对HIV病毒载量产生影响。但是，需要进行进一步的研究来阐明这种病毒相互作用中涉及的分子和细胞机制，以前在其他研究中已有报道，目的是促进开发新的抗HIV药物靶标。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号