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首页> 外文期刊>The pharmacogenomics journal >Algorithm for predicting low maintenance doses of warfarin using age and polymorphisms in genes CYP2C9 and VKORC1 in Brazilian subjects
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Algorithm for predicting low maintenance doses of warfarin using age and polymorphisms in genes CYP2C9 and VKORC1 in Brazilian subjects

机译：巴西科技基因CYP2C9和VKORC1中年龄和多态性预测Warfarin的低维护剂量的算法

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摘要

Warfarin exhibits a wide variation in dose requirements. We sought to evaluate the association of polymorphisms CYP2C9*2 (rs1799853), CYP2C9*3 (rs1075910), and VKORC1-G1639A (rs9923231) and nongenetic factors with maintenance doses of warfarin <17.5 mg/week and to create an algorithm to predict drug sensitivity. This is a retrospective cohort study including 312 patients assisted at an anticoagulation clinic in Brazil. The mean age of participants was 60.4 +/- 13.5 years and 59.9% were female. The logistic regression model included: age [odds ratio (OR) 1.03, 95% confidence interval (CI) 1.01-1.06], genotype VKORC1 AA (OR 31.61, 95% CI 11.20-100.15) and genotype CYP2C9 2/2, 2/3 or 3/3 (OR 16.48, 95% CI 3.37-81.79). The creation of our algorithm involved warfarin-experienced patients on stable doses, identifying factors associated with drug sensitivity. The validation of this algorithm allows its use in future populations to determine the initial dose distinguishing patients with dose requirements <17.5 mg and reducing time to achieve stable doses.
机译：华法林表现出宽泛的剂量要求。我们试图评估多态性CYP2C9 * 2（RS1799853），CYP2C9 * 3（RS1075910）和VKORC1-G1639A（RS9923231）和治疗剂量的治疗剂量<17.5毫克/周的环境因子，并创建预测药物的算法灵敏度。这是一种回顾性队列研究，包括312名患者，辅助巴西抗凝诊所。参与者的平均年龄为60.4 +/- 13.5岁，女性是59.9％。包括逻辑回归模型：年龄[赔率比（或）1.03，95％置信区间（CI）1.01-1.06]，基因型VKORC1 AA（或31.61,95％CI 11.20-100.15）和基因型CYP2C9 2/2，2 / 3或3/3（或16.48,95％CI 3.37-81.79）。我们的算法创建涉及Warfarin经验丰富的患者稳定剂量，识别与药物敏感性相关的因素。该算法的验证允许其在未来的群体中使用，以确定初始剂量区分剂量要求的患者<17.5mg并减少时间以获得稳定剂量。

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