Polysomnography versus limited respiratory monitoring and nurse-led titration to optimise non-invasive ventilation set-up: a pilot randomised clinical trial

Patout Maxime; Arbane Gill; Cuvelier Antoine; Muir Jean Francois; Hart Nicholas; Murphy Patrick Brian

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Polysomnography versus limited respiratory monitoring and nurse-led titration to optimise non-invasive ventilation set-up: a pilot randomised clinical trial

机译：PolysomNography与有限的呼吸监测和护士LED滴定进行优化非侵入式通风设置：试点随机临床试验

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Polysomnography (PSG) is recommended for non-invasive ventilation (NIV) set-up in patients with chronic respiratory failure. In this pilot randomised clinical trial, we compared the physiological effectiveness of NIV set-up guided by PSG to limited respiratory monitoring (LRM) and nurse-led titration in patients with COPD-obstructive sleep apnoea (OSA) overlap. The principal outcome of interest was change in daytime arterial partial pressure of carbon dioxide (PaCO2) at 3 months. Fourteen patients with daytime PaCO2 6 kPa and body mass index 30 kg/m(2) were recruited. At 3 months, PaCO2 was reduced by -0.88 kPa (95% CI -1.52 to -0.24 kPa) in the LRM group and by -0.36 kPa (95% CI -0.96 to 0.24 kPa) in the PSG group. These pilot data provide support to undertake a clinical trial investigating the clinical effectiveness of attended limited respiratory monitoring and PSG to establish NIV in patients with COPD-OSA overlap. Trial number .

机译：推荐用于慢性呼吸衰竭患者的非侵入性通气（NIV）设置的多腹漆（PSG）。在该试点随机临床试验中，我们将NIV设置的生理有效性与PSG引导的NIV设置为有限的呼吸监测（LRM）和护士LED滴定在COPD阻塞性睡眠呼吸暂停（OSA）重叠患者中。兴趣的主要结果是白天动脉部分压力发生在3个月内二氧化碳（PACO2）的变化。 14例白天Paco2＆ 6 kPa和体重指数＆ 30kg / m（2）被招募。在3个月内，PACO2在LRM组中减少-0.88kPa（95％CI -1.52至-0.24kPa），在PSG组中均为-0.36kPa（95％CI -0.96至0.24kPa）。这些导频数据提供了临床试验，调查参加有限呼吸监测和PSG在COPD-OSA重叠患者中建立NIV的临床试验。试用号码。

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《Thorax: The Journal of the British Thoracic Society》 |2019年第1期|共4页
作者
Patout Maxime; Arbane Gill; Cuvelier Antoine; Muir Jean Francois; Hart Nicholas; Murphy Patrick Brian;
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作者单位

Guys &

St Thomas NHS Fdn Trust Lane Fox Resp Unit London England;

Guys &

St Thomas NHS Fdn Trust Lane Fox Resp Unit London England;

Normandie Univ Serv Pneumol Oncol Thorac &

Soins Intensifs Resp UNIRouen Rouen Univ Hosp IRIB;

Normandie Univ Serv Pneumol Oncol Thorac &

Soins Intensifs Resp UNIRouen Rouen Univ Hosp IRIB;

Guys &

St Thomas NHS Fdn Trust Lane Fox Resp Unit London England;

Guys &

St Thomas NHS Fdn Trust Lane Fox Resp Unit London England;

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正文语种 eng
中图分类呼吸系及胸部疾病;
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1. Polysomnography versus limited respiratory monitoring and nurse-led titration to optimise non-invasive ventilation set-up: a pilot randomised clinical trial [J] . Patout Maxime, Arbane Gill, Cuvelier Antoine, Thorax: The Journal of the British Thoracic Society . 2019,第1期

机译：PolysomNography与有限的呼吸监测和护士LED滴定进行优化非侵入式通风设置：试点随机临床试验
2. Medium-term cost-effectiveness of an automated non-invasive ventilation outpatient set-up versus a standard fixed level non-invasive ventilation inpatient set-up in obese patients with chronic respiratory failure: a protocol description [J] . A Cuvelier, A Douiri, D Parkin, BMJ Open . 2015,第4期

机译：肥胖慢性呼吸衰竭患者的自动化无创通气门诊设置与标准固定水平无创通气住院门诊设置的中期成本效益：方案说明
3. Randomised trial of volume-targeted ventilation versus pressure-limited ventilation in acute respiratory failure in prematurely born infants [J] . ChowdhuryO., PatelD.-S., HannamS., Neonatology . 2013,第4期

机译：早产儿急性呼吸衰竭时以体积为目标的通气与限压通气的随机试验
4. Clinical Utilisation of Respiratory Elastance (CURE): Pilot Trials for the Optimisation of Mechanical Ventilation Settings for the Critically III [C] . Shaun M. Davidson, Daniel P. Redmond, Hamish Laing, IFAC World Congress . 2014

机译：呼吸弹性（固化）的临床利用率：用于优化批判性III的机械通风环境的试验试验
5. Medium-term cost-effectiveness of an automated non-invasive ventilation outpatient set-up versus a standard fixed level non-invasive ventilation inpatient set-up in obese patients with chronic respiratory failure: a protocol description [O] . S Mandal, G Arbane, P Murphy, 2015

机译：肥胖慢性呼吸衰竭患者的自动无创通气门诊设置与标准固定水平无创通气住院门诊设置的中期成本效益：方案说明
6. Respiratory support in COPD patients after acute exacerbation with monitoring the quality of support (Rescue2-monitor): an open-label, prospective randomized, controlled, superiority clinical trial comparing hospital- versus home-based acute non-invasive ventilation for patients with hypercapnic chronic obstructive pulmonary disease [O] . 2020

机译：COPD患者急性加剧后的呼吸障碍，监测支持质量（Rescue2-Monitor）：开放式，前瞻性随机，控制，优势临床试验，比较医院 - 与高速慢性患者患者的医院 - 与家庭急性无侵入性通风阻塞性肺疾病

Polysomnography versus limited respiratory monitoring and nurse-led titration to optimise non-invasive ventilation set-up: a pilot randomised clinical trial

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