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首页> 外文期刊>Thorax: The Journal of the British Thoracic Society >Patient outcomes from time of listing for lung transplantation in the UK: are there disease-specific differences?
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Patient outcomes from time of listing for lung transplantation in the UK: are there disease-specific differences?

机译：患者结果从英国肺移植时代的时间：有特定疾病的差异吗？

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Background The demand for lung transplantation vastly exceeds the availability of donor organs. This translates into long waiting times and high waiting list mortality. We set out to examine factors influencing patient outcomes from the time of listing for lung transplantation in the UK, examining for differences by patient characteristics, lung disease category and transplant centre. Methods Data were obtained from the UK Transplant Registry held by NHS Blood and Transplant for adult lung-only registrations between 1January 2004 and 31 March 2014. Pretransplant and post-transplant outcomes were evaluated against lung disease category, blood group and height. Results Of the 2213 patient registrations, COPD comprised 28.4%, pulmonary fibrosis (PF) 26.2%, cystic fibrosis (CF) 25.4% and other lung pathologies 20.1%. The chance of transplantation after listing differed by the combined effect of disease category and centre (p0.001). At 3 years postregistration, 78% of patients with COPD were transplanted followed by 61% of patients with CF, 59% of other lung pathology patients and 48% of patients with PF, who also had the highest waiting list mortality (37%). The chance of transplantation also differed by height with taller patients having a greater chance of transplant (HR: 1.03, 95% CI: 1.02 to 1.04, p0.001). Patients with blood group O had the highest waiting mortality at 3 years postregistration compared with all other blood groups (27% vs 20%, p0.001). Conclusions The way donor lungs were allocated in the UK resulted in discrepancies between the risk profile and probability of lung transplantation. A new donor lung allocation scheme was introduced in 2017 to try to address these shortcomings.
机译：背景，对肺移植的需求大大超过供体器官的可用性。这转化为漫长的等待时间和高等待列表死亡率。我们开始研究影响英国肺移植列表的影响因素，检查患者特征，肺病类和移植中心的差异。方法从NHS血液持有的英国移植登记处获得数据，并在2004年3月1日和2014年3月3日之间进行成人肺部登记。预防肺病类别，血液组和高度进行了预防植物和移植后的结果。结果2213患者注册，COPD组成28.4％，肺纤维化（PF）26.2％，囊性纤维化（CF）25.4％等肺病理20.1％。列表后移植的机会因疾病类别和中心的组合效应而异（P <0.001）不同。在3年后，78％的COPD患者移植，其次有61％的CF患者，其他肺病理学患者和48％的PF患者，也有最高的等候名单死亡率（37％）。移植的机会也有高度不同，具有更大的移植机会的较高患者（HR：1.03,95％CI：1.02至1.04，P <0.001）。血液组患者o与所有其他血液组相比，血液组o的等候死亡率最高（27％vs 20％，p <0.001）。结论供体肺分配在英国的方式导致风险概况和肺移植概率之间的差异。 2017年推出了新的捐助肺部分配计划，以解决这些缺点。

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