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首页> 外文期刊>AIDS Research and Human Retroviruses >Pulmonary vascular lesions are common in SIV- and SHIV-env-infected macaques.
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Pulmonary vascular lesions are common in SIV- and SHIV-env-infected macaques.

机译：肺血管病变在SIV和SHIV感染的猕猴中很常见。

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The lack of animal models of HIV-related pulmonary arterial hypertension (HIV-PAH) severely limits investigation of this serious disease. While histological evidence of HIV-PAH has been demonstrated in macaques infected with simian immunodeficiency virus (SIV) as well as with chimeric simian/human immunodeficiency virus (SHIV) containing HIV-1-derived Nef protein, other primate models have not been studied. The objective was to document and describe the development of pulmonary vascular changes in macaques infected with SIV or with SIV containing HIV-1-derived envelope protein (SHIV-env). Lung tissue was obtained at necropsy from 13 SHIV (89.6P)-env-infected macaques and 10 SIV (DeltaB670)-infected macaques. Pulmonary arterial pathology, including arterial hyperplasia and the presence of plexiform lesions, was compared to normal monkey lung. Pulmonary artery hyperplasia was present in 8 of 13 (62%) SHIV-env-infected macaques and 4/10 (36%) SIV-infected macaques. The most common histopathological lesions were intimal and medial hyperplasia of medium and large pulmonary arteries. Hyperplastic lesions were predominantly due to smooth muscle cell hyperplasia. This is the first report of pulmonary vascular lesions in SHIV-env-infected macaques and confirms prior reports of pulmonary vasculopathy in SIV-infected macaques. The finding of pulmonary arteriopathy in monkeys infected with SHIV not containing HIV-nef suggests that other factors might also be important in the development of HIV-PAH. This SHIV-env model provides a new means to investigate HIV-PAH.
机译：缺乏与HIV相关的肺动脉高压（HIV-PAH）的动物模型，严重限制了对该严重疾病的研究。虽然已在感染猿猴免疫缺陷病毒（SIV）的猕猴以及含有HIV-1衍生的Nef蛋白的嵌合猿猴/人类免疫缺陷病毒（SHIV）的猕猴中证实了HIV-PAH的组织学证据，但尚未研究其他灵长类动物模型。目的是记录和描述感染SIV或感染HIV-1的包膜蛋白（SHIV-env）的SIV的猕猴的肺血管变化。尸检时，从感染了13只SHIV（89.6P）的猕猴和感染了10只SIV（DeltaB670）的猕猴中获得了肺组织。肺动脉病理，包括动脉增生和丛状病变的存在，与正常猴肺进行了比较。肺动脉增生存在于13只SIV感染的猕猴中的8只（62％）和SIV感染的猕猴中的4/10（36％）。最常见的组织病理学病变是中，大型肺动脉的内膜和内膜增生。增生性病变主要归因于平滑肌细胞增生。这是在SHIV感染的猕猴中发生肺血管病变的首例报道，并证实了先前在SIV感染的猕猴中发生肺血管病变的报道。在感染了不含HIV-nef的SHIV的猴子中发现肺动脉病表明，其他因素在HIV-PAH的发生中也可能很重要。这种SHIV-env模型为研究HIV-PAH提供了新的手段。

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