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HIV variability in the liver and evidence of possible compartmentalization.

机译：肝脏中的HIV变异性和可能的​​分隔性证据。

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There is growing evidence to suggest that HIV may interact with several hepatic cell types; however, evaluation of HIV variability in liver tissue has not been addressed to date. Among 16 HIV-positive individuals examined, nine (56%) had detectable HIV RNA in the liver. The mean CD4 cell count for these nine individuals was 337 cells/mm(3) (range: 0-601), while their mean plasma HIV RNA level was 106,974 copies/ml (range: 1200-320,740). Among individuals in this study with detectable HIV in both the plasma and the liver, the consensus gag nucleotide sequences for each tissue type were different for seven of seven (100%) individuals, while amino acid sequences were distinct for five of seven (71%). Consensus envelope (env) nucleotide and amino acid sequences were also distinct in the plasma and liver tissue for six of six (100%) individuals. Statistical evidence of compartmentalization between HIV in the plasma and in the liver was demonstrated, and multiple liver-specific amino acids were identified that may distinguish HIV variants replicating within the liver. These preliminary data demonstrate that HIV is frequently detectable in the liver of HIV-positive persons at various levels of immunosuppression. Possible compartmentalization may reflect tissue-specific selection pressures that drive viral adaptation to the liver microenvironment and may facilitate interactions with other hepatotropic viruses.
机译：越来越多的证据表明，HIV可能与几种肝细胞相互作用。然而，迄今为止，尚未评估肝组织中HIV变异性的评估。在接受检查的16名HIV阳性个体中，有9名（56％）的肝中检测到HIV RNA。这9个人的平均CD4细胞计数为337细胞/ mm（3）（范围：0-601），而他们的血浆HIV RNA水平平均为106,974拷贝/ ml（范围：1200-320,740）。在这项研究中，血浆和肝脏中均可检测到HIV的个体中，七种（100％）个体中有七种（100％）个体的每种组织类型的共有gag核苷酸序列不同，而七分之五（71％）中氨基酸序列不同）。对于六分之六（100％）的个体，血浆和肝组织中的共有包膜（env）核苷酸和氨基酸序列也不同。证明了血浆和肝脏中HIV之间间隔区分开的统计证据，并且鉴定了多种肝脏特异性氨基酸，可以区分在肝脏中复制的HIV变异体。这些初步数据表明，在各种免疫抑制水平下，HIV阳性患者的肝脏中经常可以检测到HIV。可能的区室化可能反映了组织特异性选择压力，这些选择压力驱动病毒适应肝微环境，并可能促进与其他肝细胞病毒的相互作用。

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